HMGCS2 Antikörper

Produktnummer ABIN6292123

Produktdetails anti-HMGCS2 Antikörper

Target: HMGCS2 (3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 (Mitochondrial) (HMGCS2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HMGCS2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human HMGCS2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000

Kommentare:

Expression in liver is 200-fold higher than in any other tissue, Low expression in colon, kidney, testis, and pancreas, Very low expression in heart and skeletal muscle, Not detected in brain, The relative expression of isoform 3 (at mRNA level) is highest in heart (70%) and skeletal muscle (60%)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20C. Avoid freeze / thaw cycles.

Details zu HMGCS2

Target: HMGCS2 (3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 (Mitochondrial) (HMGCS2))

Andere Bezeichnung: HMGCS2 (HMGCS2 Produkte)

Synonyme: 1300002P16 antikoerper, mHS antikoerper, DDBDRAFT_0219349 antikoerper, DDBDRAFT_0219924 antikoerper, DDB_0219349 antikoerper, DDB_0219924 antikoerper, Hmgcs1 antikoerper, Mt3h3mg antikoerper, hmgCoA antikoerper, 3-hydroxy-3-methylglutaryl-CoA synthase 2 antikoerper, 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 antikoerper, hydroxymethylglutaryl-CoA synthase antikoerper, hydroxymethylglutaryl-coa synthase antikoerper, 3-HYDROXY-3-METHYLGLUTARYL-CoA SYNTHASE 2 antikoerper, HMGCS2 antikoerper, Hmgcs2 antikoerper, mvaS antikoerper, CNC05080 antikoerper, HMCS1 antikoerper, hgsA antikoerper, MFER_RS00425 antikoerper, LOC100285783 antikoerper, ECU10_0510 antikoerper, Eint_100450 antikoerper

Hintergrund: The protein encoded by this gene belongs to the HMG-CoA synthase family. It is a mitochondrial enzyme that catalyzes the first reaction of ketogenesis, a metabolic pathway that provides lipid-derived energy for various organs during times of carbohydrate deprivation, such as fasting. Mutations in this gene are associated with HMG-CoA synthase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 56.635 kDa

Gen-ID: 3158

UniProt: P54868

Pathways: Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha