IBTK Antikörper

Produktnummer ABIN6290521

Produktdetails anti-IBTK Antikörper

Target: IBTK (Inhibitor of Bruton Agammaglobulinemia Tyrosine Kinase (IBTK))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IBTK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human IBTK

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000

Kommentare:

Expressed in DeFew, HEK293T, HeLa and in Jurkat, MC3 and NB4 lymphoid cells (at protein level), Isoform 1 is the predominant isoform expressed in all examined tissues and cell lines, Highly expressed in hemopoietic tissues (fetal liver, spleen, lymph node, thymus, peripheral blood leukocytes and bone marrow), Weakly or not expressed in other tissues

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20C. Avoid freeze / thaw cycles.

Details zu IBTK

Target: IBTK (Inhibitor of Bruton Agammaglobulinemia Tyrosine Kinase (IBTK))

Andere Bezeichnung: IBTK (IBTK Produkte)

Synonyme: IBTK antikoerper, fi40c08 antikoerper, wu:fi40c08 antikoerper, DKFZp468J085 antikoerper, BTBD26 antikoerper, BTKI antikoerper, RP1-93K22.1 antikoerper, 5430411K16Rik antikoerper, AA409502 antikoerper, mKIAA1417 antikoerper, inhibitor of Bruton tyrosine kinase antikoerper, inhibitor of Bruton agammaglobulinemia tyrosine kinase antikoerper, inhibitor of Bruton tyrosine kinase L homeolog antikoerper, IBTK antikoerper, ibtk antikoerper, Ibtk antikoerper, ibtk.L antikoerper

Hintergrund: Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Molekulargewicht: 150.528 kDa

Gen-ID: 25998

UniProt: Q9P2D0