GSK3 alpha/beta Antikörper (pTyr216, pTyr279)

Produktnummer ABIN6288285

Produktdetails anti-GSK3 alpha/beta Antikörper

Target: GSK3 alpha/beta (GSK3a/b) (Glycogen Synthase Kinase 3 alpha/beta (GSK3a/b))

Bindungsspezifität: AA 220-300, pTyr216, pTyr279

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GSK3 alpha/beta Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: GSK3α/β is a protein encoded by the GSK3A gene which is approximately 50,9 kDa. GSK3α/β is localised to the mitochondrion. It is involved in the common cytokine receptor gamma-chain family signalling pathways, RET signalling and activation of cAMP-dependent PKA. It is a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also acts as a negative regulator in the hormonal control of glucose homeostasis. GSK3α/β is expressed in the nervous system, liver, eye, pancreas and muscle. Mutations in the GSK3A gene may result in Alzheimer disease. STJ90283 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous GSK3α/β protein which only binds about Y279/216 when Y279/216 is phosphorylated.

Spezifität: Phospho-GSK3α/β (Y279/216) Polyclonal Antibody detects endogenous levels of GSK3α/β protein only when phosphorylated at Y279/216.

Produktmerkmale: Rabbit polyclonal to Phospho-GSK3α/β (Y279/216).

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human GSK3alpha/beta around the phosphorylation site of Y279/216.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C, and avoid repeat freeze-thaw cycles.

Details zu GSK3 alpha/beta

Target: GSK3 alpha/beta (GSK3a/b) (Glycogen Synthase Kinase 3 alpha/beta (GSK3a/b))

Andere Bezeichnung: GSK3alpha/beta (GSK3a/b Produkte)

Molekulargewicht: 51 kDa

Gen-ID: 2931

UniProt: P49840