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GSK3 alpha/beta Antikörper

GSK3a/b Reaktivität: Human, Ratte, Maus WB, ELISA, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7251145
  • Target Alle GSK3 alpha/beta (GSK3a/b) Produkte
    GSK3 alpha/beta (GSK3a/b) (Glycogen Synthase Kinase 3 alpha/beta (GSK3a/b))
    Reaktivität
    • 28
    • 27
    • 27
    • 4
    • 1
    • 1
    • 1
    Human, Ratte, Maus
    Wirt
    • 27
    • 1
    Kaninchen
    Klonalität
    • 25
    • 3
    Polyklonal
    Konjugat
    • 13
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser GSK3 alpha/beta Antikörper ist unkonjugiert
    Applikation
    • 28
    • 15
    • 14
    • 14
    • 9
    • 8
    • 7
    • 4
    • 3
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Produktmerkmale
    Polyclonal Antibody
    Aufreinigung
    Affinity purification
    Immunogen
    Synthesized peptide derived from human GSK3alpha/beta around the non-phosphorylation site of Tyr279/216.
    Isotyp
    IgG
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:20000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol, pH 7.4
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    GSK3 alpha/beta (GSK3a/b) (Glycogen Synthase Kinase 3 alpha/beta (GSK3a/b))
    Andere Bezeichnung
    GSK3 alpha/beta (GSK3a/b Produkte)
    Hintergrund
    Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin. GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3 kinase/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3βGSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus and mammalian development. GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization.
    Molekulargewicht

    Observed_MW: 51,46 kDa

    Calculated_MW: 51 kDa

    UniProt
    P49840, P49841
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