Neuregulin 1 Antikörper (N-Term)

Produktnummer ABIN6287523

Produktdetails anti-Neuregulin 1 Antikörper

Target: Neuregulin 1 (NRG1)

Bindungsspezifität: AA 1-80, N-Term

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Neuregulin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Verwendungszweck: Neuregulin-1 SMDF is a protein encoded by the NRG1 gene which is approximately 70,3 kDa. Neuregulin-1 SMDF is secreted and some isoforms are localised to the nucleus. It is involved in RET signalling, apoptotic pathways in synovial fibroblasts, GAB1 signalosome and the GPCR pathway. It mediates cell-cell signalling and plays a critical role in the growth and development of multiple organ systems. It is also a direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Neuregulin-1 SMDF isoform type 1 is the predominant form expressed in the endocardium. Mutations in the NRG1 gene may result in schizophrenia and bipolar disorder. STJ94419 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Neuregulin-1 SMDF protein.

Spezifität: Neuregulin-1 SMDF Polyclonal Antibody detects endogenous levels of Neuregulin-1 SMDF protein.

Produktmerkmale: Rabbit polyclonal to Neuregulin-1 SMDF.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human Neuregulin-1 SMDF

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:10000

Kommentare:

Type I isoforms are the predominant forms expressed in the endocardium. Isoform alpha is expressed in breast, ovary, testis, prostate, heart, skeletal muscle, lung, placenta liver, kidney, salivary gland, small intestine and brain, but not in uterus, stomach, pancreas, and spleen. Isoform 3 is the predominant form in mesenchymal cells and in non-neuronal organs, whereas isoform 6 is the major neuronal form. Isoform 8 is expressed in spinal cord and brain. Isoform 9 is the major form in skeletal muscle cells, in the nervous system it is expressed in spinal cord and brain. Also detected in adult heart, placenta, lung, liver, kidney, and pancreas. Isoform 10 is expressed in nervous system: spinal cord motor neurons, dorsal root ganglion neurons, and brain. Predominant isoform expressed in sensory and motor neurons. Not detected in adult heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Not expressed in fetal lung, liver and kidney. Type IV isoforms are brain-specific.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C, and avoid repeat freeze-thaw cycles.

Details zu Neuregulin 1

Target: Neuregulin 1 (NRG1)

Andere Bezeichnung: Neuregulin-1 SMDF (NRG1 Produkte)

Synonyme: 6030402G23Rik antikoerper, ARIA antikoerper, D230005F13Rik antikoerper, GGF antikoerper, GGFII antikoerper, HRG antikoerper, HRGalpha antikoerper, Hgl antikoerper, NDF antikoerper, SMDF antikoerper, GGF2 antikoerper, HGL antikoerper, HRG1 antikoerper, HRGA antikoerper, MST131 antikoerper, NRG-1 antikoerper, heregulin antikoerper, nrg1-A antikoerper, pro-neuregulin-1 antikoerper, NRG1 antikoerper, wu:fm70e01 antikoerper, DKFZp459A1838 antikoerper, neuregulin 1 antikoerper, histidine rich glycoprotein antikoerper, neuregulin 1 L homeolog antikoerper, Nrg1 antikoerper, NRG1 antikoerper, HRG antikoerper, nrg1.L antikoerper, nrg1 antikoerper

Molekulargewicht: 44 kDa

UniProt: Q02297

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Muscle Cell Differentiation