Caspase-8 p18 Antikörper (Cleaved-Ser217, Internal Region)

Produktnummer ABIN6281720

Produktdetails anti-Caspase-8 p18 Antikörper

Target: Caspase-8 p18 (Caspase 8 Subunit P18)

Bindungsspezifität: AA 170-250, Cleaved-Ser217, Internal Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Caspase-8 p18 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Verwendungszweck: Caspase-8 is a protein encoded by the CASP8 gene which is approximately 55,3 kDa. Caspase-8 is localised to the cytoplasm and is involved in the TNFR1 pathway, dimerization of procaspase-8 , activated TLR4 signalling, apoptosis signalling and toll-like receptor signalling pathways. This protein falls under the cysteine-aspartic acid protease family. It pays a role in the programmed cell death induced by Fas and various apoptotic stimuli. Caspase-8 isoform 1, 5 and 7 are expressed in a wide variety of tissues. Mutations in the CASP8 gene may result in a caspase-8 deficiency. STJ97641 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.This polyclonal antibody detects endogenous levels of fragment of activated caspase-8 p18 protein resulting from cleavage adjacent to S217.

Spezifität: Cleaved-Caspase-8 p18 (S217) Polyclonal Antibody detects endogenous levels of Cleaved-Caspase-8 p18 (S217) protein.

Produktmerkmale: Rabbit polyclonal to Cleaved-Caspase-8 p18 (S217).

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human Cleaved-Caspase-8 p18 (S217)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000
ELISA 1:10000

Kommentare:

Isoform 1, isoform 5 and isoform 7 are expressed in a wide variety of tissues. Highest expression in peripheral blood leukocytes, spleen, thymus and liver. Barely detectable in brain, testis and skeletal muscle.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C, and avoid repeat freeze-thaw cycles.

Details zu Caspase-8 p18

Target: Caspase-8 p18 (Caspase 8 Subunit P18)

Andere Bezeichnung: Caspase-8 p18 (Caspase-8 p18 Produkte)

Synonyme: ALPS2B antikoerper, CAP4 antikoerper, Casp-8 antikoerper, FLICE antikoerper, MACH antikoerper, MCH5 antikoerper, CASP-8 antikoerper, Mch5 antikoerper, caspase 8 antikoerper, CASP8 antikoerper, Casp8 antikoerper

Gen-ID: 841

UniProt: Q14790