Caspase-8 p18 Produkte
(Caspase 8 Subunit P18)
Kategorien
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008].
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Empfohlene Caspase-8 p18 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA
Validierungen
- (2)
Kat. Nr.
ABIN3188085
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IF
Validierungen
Kat. Nr.
ABIN6281720
Menge
50 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB
Validierungen
Kat. Nr.
ABIN7302572
Menge
100 μL
Datenblatt
Datenblatt
Synonyme und alternative Namen zu Caspase-8 p18
caspase 8 (CASP8), caspase 8 (Casp8), ALPS2B, CAP4, Casp-8, CASP-8, FLICE, MACH, MCH5, Mch5Bezeichner auf Proteinebene für Caspase-8 p18
- FADD-homologous ICE/CED-3-like protease
- FADD-like ICE
- ICE-like apoptotic protease 5
- MACH-alpha-1/2/3 protein
- MACH-beta-1/2/3/4 protein
- MORT1-associated ced-3 homolog
- apoptotic cysteine protease
- apoptotic protease Mch-5
- caspase 8, apoptosis-related cysteine protease
- caspase-8
- Fas-linked ICE-like protease
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