Nuclear Receptor Subfamily 4, Group A, Member 3 (NR4A3) Antikörper

Details zu Produkt Nr. ABIN6266760
Antigen
  • CHN
  • CSMF
  • MINOR
  • NOR1
  • TEC
  • AI573420
  • NOR-1
  • Nor1
  • NOR-2
  • NR4A3
  • Nr4a3
  • nuclear receptor subfamily 4 group A member 3
  • nuclear receptor subfamily 4, group A, member 3
  • NR4A3
  • Nr4a3
  • nr4a3
Reaktivität
Human, Maus, Ratte (Rattus)
190
87
66
7
7
6
6
5
5
4
4
3
2
Wirt
Kaninchen
175
36
Klonalität
Polyklonal
Konjugat
Unkonjugiert
11
11
10
10
8
8
3
3
3
3
3
3
2
2
2
2
2
Applikation
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
156
86
35
31
26
8
3
3
3
3
2
Optionen
Immunogen A synthesized peptide derived from human NR4A3
Isotyp IgG
Spezifität NR4A3 antibody detects endogenous levels of total NR4A3
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
Antigen
Andere Bezeichnung NR4A3 (NR4A3 Antibody Abstract)
Hintergrund

Description: Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner. Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5'-AAAAGGTCA-3' site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes (By similarity). Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation. Mediates proliferation of vascular smooth muscle, myeloid progenitor cell and type B pancreatic cells, promotes mitogen-induced vascular smooth muscle cell proliferation through transactivation of SKP2 promoter by binding a NBRE site (By similarity). Upon PDGF stimulation, stimulates vascular smooth muscle cell proliferation by regulating CCND1 and CCND2 expression. In islets, induces type B pancreatic cell proliferation through up-regulation of genes that activate cell cycle, as well as genes that cause degradation of the CDKN1A (By similarity). Negatively regulates myeloid progenitor cell proliferation by repressing RUNX1 in a NBRE site-independent manner. During inner ear, plays a role as a key mediator of the proliferative growth phase of semicircular canal development (By similarity). Mediates also survival of neuron and smooth muscle cells, mediates CREB-induced neuronal survival, and during hippocampus development, plays a critical role in pyramidal cell survival and axonal guidance. Is required for S phase entry of the cell cycle and survival of smooth muscle cells by inducing CCND1, resulting in RB1 phosphorylation. Binds to NBRE motif in CCND1 promoter, resulting in the activation of the promoter and CCND1 transcription (By similarity). Plays also a role in inflammation, upon TNF stimulation, mediates monocyte adhesion by inducing the expression of VCAM1 and ICAM1 by binding to the NBRE consensus site (By similarity) (PubMed:20558821). In mast cells activated by Fc-epsilon receptor cross-linking, promotes the synthesis and release of cytokines but impairs events leading to degranulation (By similarity). Plays also a role in metabolism, by modulating feeding behavior, and by playing a role in energy balance by inhibiting the glucocorticoid-induced orexigenic neuropeptides AGRP expression, at least in part by forming a complex with activated NR3C1 on the AGRP- glucocorticoid response element (GRE), and thus weakening the DNA binding activity of NR3C1. Upon catecholamines stimulation, regulates gene expression that controls oxidative metabolism in skeletal muscle (By similarity). Plays a role in glucose transport by regulating translocation of the SLC2A4 glucose transporter to the cell surface (PubMed:24022864). Finally, during gastrulation plays a crucial role in the formation of anterior mesoderm by controlling cell migration. Inhibits adipogenesis (By similarity). Also participates in cardiac hypertrophy by activating PARP1 (By similarity).

Gene: NR4A3

Molekulargewicht 65kDa
Gen-ID 8013
UniProt Q92570
Pathways Fc-epsilon Rezeptor Signalübertragung, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway
Applikations-hinweise WB: 1:500~1:3000, IF/ICC 1:100-1:500
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder des Herstellers
Western Blotting (WB) image for anti-Nuclear Receptor Subfamily 4, Group A, Member 3 (NR4A3) antibody (ABIN6266760) Western blot analysis on COLO205 cell lysate using NR4A3 Antibody,The lane on the lef...
Immunofluorescence (fixed cells) (IF/ICC) image for anti-Nuclear Receptor Subfamily 4, Group A, Member 3 (NR4A3) antibody (ABIN6266760) ABIN6266760 staining COLO205 by IF/ICC. The sample were fixed with PFA and permeabili...
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