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ZCCHC11 Antikörper (Internal Region)

ZCCHC11 Reaktivität: Human, Maus, Ratte WB, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6266092
  • Target Alle ZCCHC11 Antikörper anzeigen
    ZCCHC11 (Zinc Finger, CCHC Domain Containing 11 (ZCCHC11))
    Bindungsspezifität
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 14
    • 7
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 13
    • 2
    • 2
    Kaninchen
    Klonalität
    • 17
    Polyklonal
    Konjugat
    • 17
    Dieser ZCCHC11 Antikörper ist unkonjugiert
    Applikation
    • 15
    • 4
    • 4
    • 4
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    ZCCHC11 Antibody detects endogenous levels of total ZCCHC11.
    Homologie
    Chicken
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human ZCCHC11, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product ZCCHC11 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    ZCCHC11 (Zinc Finger, CCHC Domain Containing 11 (ZCCHC11))
    Andere Bezeichnung
    ZCCHC11 (ZCCHC11 Produkte)
    Synonyme
    PAPD3 antikoerper, TUT4 antikoerper, ZCCHC11 antikoerper, DKFZp459G145 antikoerper, 6030404K05Rik antikoerper, 9230115F04Rik antikoerper, PPAPD3 antikoerper, mKIAA0191 antikoerper, wu:fc06h08 antikoerper, wu:fy37g11 antikoerper, papd3 antikoerper, zinc finger CCHC-type containing 11 antikoerper, zinc finger, CCHC domain containing 11 antikoerper, zinc finger CCHC domain containing 11 antikoerper, ZCCHC11 antikoerper, Zcchc11 antikoerper, zcchc11 antikoerper
    Hintergrund

    Description: Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:25480299). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7), miR107, miR-143 and miR-200c. Uridylated miRNAs are not processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cell pluripotency (By similarity). Does not bind RNA directly, but recruited to RNA targets by RNA-binding protein LIN28A. Also catalyzes the 3' uridylation of miR-26A, a miRNA that targets IL6 transcript. This abrogates the silencing of IL6 transcript, hence promoting cytokine expression (By similarity). May also suppress Toll-like receptor-induced NF-kappa-B activation via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation. Due to functional redundancy between ZCCHC6 and ZCCHC11, the identification of the specific role of each of these proteins is difficult.

    Gene: ZCCHC11

    Molekulargewicht
    185 kDa
    Gen-ID
    23318
    UniProt
    Q5TAX3
    Pathways
    Stem Cell Maintenance
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