ZCCHC11 Antikörper (C-Term)

Produktnummer ABIN6242704

Produktdetails anti-ZCCHC11 Antikörper

Target: ZCCHC11 (Zinc Finger, CCHC Domain Containing 11 (ZCCHC11))

Bindungsspezifität: AA 1568-1600, C-Term

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZCCHC11 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This (Mouse) Zcchc11 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1568-1600 amino acids from the C-terminal region of (Mouse) Zcchc11.

Klon: RB51164

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu ZCCHC11

Target: ZCCHC11 (Zinc Finger, CCHC Domain Containing 11 (ZCCHC11))

Andere Bezeichnung: Zcchc11 (ZCCHC11 Produkte)

Synonyme: PAPD3 antikoerper, TUT4 antikoerper, ZCCHC11 antikoerper, DKFZp459G145 antikoerper, 6030404K05Rik antikoerper, 9230115F04Rik antikoerper, PPAPD3 antikoerper, mKIAA0191 antikoerper, wu:fc06h08 antikoerper, wu:fy37g11 antikoerper, papd3 antikoerper, zinc finger CCHC-type containing 11 antikoerper, zinc finger, CCHC domain containing 11 antikoerper, zinc finger CCHC domain containing 11 antikoerper, ZCCHC11 antikoerper, Zcchc11 antikoerper, zcchc11 antikoerper

Hintergrund: Uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. Catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre- let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. Does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28A and LIN28B (By similarity). Also catalyzes the 3' uridylation of miR- 26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression. May also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation (By similarity).

Molekulargewicht: 184650

UniProt: B2RX14

Pathways: Stem Cell Maintenance