ZC3HAV1 Antikörper (Internal Region)

Produktnummer ABIN6266091

Produktdetails anti-ZC3HAV1 Antikörper

Target: ZC3HAV1 (Zinc Finger CCCH-Type, Antiviral 1 (ZC3HAV1))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZC3HAV1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: ZC3HAV1 Antibody detects endogenous levels of total ZC3HAV1.

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ZC3HAV1, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu ZC3HAV1

Target: ZC3HAV1 (Zinc Finger CCCH-Type, Antiviral 1 (ZC3HAV1))

Andere Bezeichnung: ZC3HAV1 (ZC3HAV1 Produkte)

Synonyme: 1200014N16Rik antikoerper, 2900058M19Rik antikoerper, 9130009D18Rik antikoerper, 9830115L13Rik antikoerper, ARTD13 antikoerper, D6Bwg1452e antikoerper, ZAP antikoerper, Zap antikoerper, FLB6421 antikoerper, PARP13 antikoerper, ZC3H2 antikoerper, ZC3HDC2 antikoerper, zinc finger CCCH type, antiviral 1 antikoerper, zinc finger CCCH-type containing, antiviral 1 antikoerper, Zc3hav1 antikoerper, ZC3HAV1 antikoerper

Hintergrund:

Description: Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs).

Gene: ZC3HAV1

Molekulargewicht: 100 kDa

Gen-ID: 56829

UniProt: Q7Z2W4