U2AF2 Antikörper (Internal Region)

Produktnummer ABIN6265832

Produktdetails anti-U2AF2 Antikörper

Target: U2AF2 (U2AF59) (U2 Small Nuclear RNA Auxiliary Factor 2 (U2AF59))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser U2AF2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Spezifität: U2AF2 Antibody detects endogenous levels of total U2AF2.

Homologie: Pig,Bovine,Horse,Sheep,Dog,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human U2AF2, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu U2AF2

Target: U2AF2 (U2AF59) (U2 Small Nuclear RNA Auxiliary Factor 2 (U2AF59))

Andere Bezeichnung: U2AF2 (U2AF59 Produkte)

Synonyme: U2AF65 antikoerper, 65kDa antikoerper, u2af65 antikoerper, U2AF2 antikoerper, DDBDRAFT_0186947 antikoerper, DDBDRAFT_0233353 antikoerper, DDB_0186947 antikoerper, DDB_0233353 antikoerper, zgc:110115 antikoerper, U2 small nuclear RNA auxiliary factor 2 antikoerper, U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2 antikoerper, U2 small nuclear RNA auxiliary factor 2 S homeolog antikoerper, RNA recognition motif-containing protein RRM antikoerper, Splicing factor U2AF 65 kDa subunit antikoerper, U2 small nuclear RNA auxiliary factor 2a antikoerper, U2AF2 antikoerper, U2af2 antikoerper, u2af2.S antikoerper, u2af2 antikoerper, u2af2a antikoerper

Hintergrund:

Description: Plays a role in pre-mRNA splicing and 3'-end processing (PubMed:17024186). By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing (PubMed:21536736). Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10. Positively regulates pre-mRNA 3'-end processing by recruiting the CFIm complex to cleavage and polyadenylation signals (PubMed:17024186).

Gene: U2AF2

Molekulargewicht: 53kDa

Gen-ID: 11338

UniProt: P26368