U2AF2 Antikörper (N-Term)

Produktnummer ABIN2778722

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch U2AF2 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Rind (Kuh), Pferd, Hund, Meerschweinchen und Zebrafisch (Danio rerio).Es wurde in 1 Publikation zitiert.

Kurzübersicht für U2AF2 Antikörper (N-Term) (ABIN2778722)

Target: U2AF2 (U2AF59) (U2 Small Nuclear RNA Auxiliary Factor 2 (U2AF59))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Pferd, Hund, Meerschweinchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser U2AF2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-U2AF2 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: U2AF2 Antibody - N-terminal region

Sequenz: EFERQLNENK QERDKENRHR KRSHSRSRSR DRKRRSRSRD RRNRDQRSAS

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against U2AF2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human U2AF2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP40284-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-U2AF2 Antikörper (ABIN2778722)

Sickmier, Frato, Kielkopf: "Crystallization and preliminary X-ray analysis of a U2AF65 variant in complex with a polypyrimidine-tract analogue by use of protein engineering." in: Acta crystallographica. Section F, Structural biology and crystallization communications, Vol. 62, Issue Pt 5, pp. 457-9, (2006) (PubMed).

Details zu U2AF2

Target: U2AF2 (U2AF59) (U2 Small Nuclear RNA Auxiliary Factor 2 (U2AF59))

Andere Bezeichnung: U2AF2

Hintergrund:

Background Information: U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. U2AF2 is the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly.U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date.

Gene Name: U2 small nuclear RNA auxiliary factor 2

Alternative Symbols: U2AF65

Protein Name: Splicing factor U2AF 65 kDa subunit

Molekulargewicht: 52kDa

Gen-ID: 11338

NCBI Accession: NP_001012496

UniProt: Q96HC5