U2AF2 Antikörper (N-Term)

Produktnummer ABIN2778722

Produktdetails anti-U2AF2 Antikörper

Target: U2AF2 (U2AF59) (U2 Small Nuclear RNA Auxiliary Factor 2 (U2AF59))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Pferd, Hund, Meerschweinchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser U2AF2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: EFERQLNENK QERDKENRHR KRSHSRSRSR DRKRRSRSRD RRNRDQRSAS

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against U2AF2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human U2AF2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 471 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-U2AF2 Antikörper (ABIN2778722)

Sickmier, Frato, Kielkopf: "Crystallization and preliminary X-ray analysis of a U2AF65 variant in complex with a polypyrimidine-tract analogue by use of protein engineering." in: Acta crystallographica. Section F, Structural biology and crystallization communications, Vol. 62, Issue Pt 5, pp. 457-9, (2006) (PubMed).

Details zu U2AF2

Target: U2AF2 (U2AF59) (U2 Small Nuclear RNA Auxiliary Factor 2 (U2AF59))

Andere Bezeichnung: U2AF2 (U2AF59 Produkte)

Synonyme: U2AF65 antikoerper, 65kDa antikoerper, u2af65 antikoerper, U2AF2 antikoerper, DDBDRAFT_0186947 antikoerper, DDBDRAFT_0233353 antikoerper, DDB_0186947 antikoerper, DDB_0233353 antikoerper, zgc:110115 antikoerper, U2 small nuclear RNA auxiliary factor 2 antikoerper, U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2 antikoerper, U2 small nuclear RNA auxiliary factor 2 S homeolog antikoerper, RNA recognition motif-containing protein RRM antikoerper, Splicing factor U2AF 65 kDa subunit antikoerper, U2 small nuclear RNA auxiliary factor 2a antikoerper, U2AF2 antikoerper, U2af2 antikoerper, u2af2.S antikoerper, u2af2 antikoerper, u2af2a antikoerper

Hintergrund: U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. U2AF2 is the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly.U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date.
Alias Symbols: U2AF65
Protein Interaction Partner: THAP1, PUF60, U2AF1, SNRPA, AES, DACH1, SUMO3, UBC, SUZ12, EED, TERF1, EZH2, RNF2, PRPF40A, TCERG1, APBB1, PIN1, SH3RF2, SRPK2, SRPK1, SF1, SRSF1, RBM39, QKI, SCAF11, PRPF3, RBM10, RBM4, SMAD5, IL7R, HNRNPK, HNRNPD, HLA-DMA, SUGP1, CCAR1, SAP30BP, RBFOX2,
Protein Size: 471

Molekulargewicht: 52 kDa

Gen-ID: 11338

NCBI Accession: NM_001012478, NP_001012496

UniProt: Q96HC5