SIAH2 Antikörper (C-Term)
-
- Target Alle SIAH2 Antikörper anzeigen
- SIAH2 (Siah E3 Ubiquitin Protein Ligase 2 (SIAH2))
-
Bindungsspezifität
- C-Term
-
Reaktivität
- Human, Maus
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser SIAH2 Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Spezifität
- SIAH2 Antibody detects endogenous levels of total SIAH2.
- Homologie
- Pig,Zebrafish,Bovine,Sheep,Rabbit,Chicken,Xenopus
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human SIAH2, corresponding to a region within C-terminal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product SIAH2 Primärantikörper
-
-
- Applikationshinweise
- WB 1:1000-3000, IHC 1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
-
- Target
- SIAH2 (Siah E3 Ubiquitin Protein Ligase 2 (SIAH2))
- Andere Bezeichnung
- SIAH2 (SIAH2 Produkte)
- Synonyme
- hSiah2 antikoerper, Xsiah-2 antikoerper, siah2-A antikoerper, xsiah2 antikoerper, AA415433 antikoerper, Sinh2 antikoerper, siah E3 ubiquitin protein ligase 2 antikoerper, siah E3 ubiquitin protein ligase 2 L homeolog antikoerper, seven in absentia 2 antikoerper, SIAH2 antikoerper, siah2.L antikoerper, Siah2 antikoerper
- Hintergrund
-
Description: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (GPS2, POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 does not. Promotes monoubiquitination of SNCA.
Gene: SIAH2
- Molekulargewicht
- 35 kDa
- Gen-ID
- 6478
- UniProt
- O43255
-