SH2D1A Antikörper (Internal Region)
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- Target Alle SH2D1A Antikörper anzeigen
- SH2D1A (SH2 Domain Containing 1A (SH2D1A))
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Bindungsspezifität
- Internal Region
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser SH2D1A Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Spezifität
- SH2D1A Antibody detects endogenous levels of total SH2D1A.
- Homologie
- Pig,Bovine,Horse,Sheep,Rabbit,Dog
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human SH2D1A, corresponding to a region within the internal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product SH2D1A Primärantikörper
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- Applikationshinweise
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
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- Target
- SH2D1A (SH2 Domain Containing 1A (SH2D1A))
- Andere Bezeichnung
- SH2D1A (SH2D1A Produkte)
- Synonyme
- DSHP antikoerper, EBVS antikoerper, IMD5 antikoerper, LYP antikoerper, MTCP1 antikoerper, SAP antikoerper, SAP/SH2D1A antikoerper, XLP antikoerper, XLPD antikoerper, RGD1562408 antikoerper, Gm686 antikoerper, SH2D1A antikoerper, SH2 domain containing 1A antikoerper, SH2D1A antikoerper, Sh2d1a antikoerper
- Hintergrund
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Description: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.
Gene: SH2D1A
- Molekulargewicht
- 14kDa
- Gen-ID
- 4068
- UniProt
- O60880
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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