PPARG Antikörper (Internal Region)

Produktnummer ABIN6264371

Produktdetails anti-PPARG Antikörper

Target: PPARG (Peroxisome Proliferator-Activated Receptor gamma (PPARG))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PPARG Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Spezifität: PPAR gamma Antibody detects endogenous levels of total PPAR gamma.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human PPAR gamma, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Referenzen für anti-PPARG Antikörper (ABIN6264371)

Song, Zhou, Peng, Tao, Yang, Xu, Peng, Ren, Xiang, Wei: "GPR120 promotes adipogenesis through intracellular calcium and extracellular signal-regulated kinase 1/2 signal pathway." in: Molecular and cellular endocrinology, Vol. 434, pp. 1-13, (2017) (PubMed).

Hu, Luo, Peng, Song, Zhou, Wei, Peng, Jiang: "Molecular cloning, expression pattern analysis of porcine Rb1 gene and its regulatory roles during primary dedifferentiated fat cells adipogenic differentiation." in: General and comparative endocrinology, Vol. 214, pp. 77-86, (2015) (PubMed).

Details zu PPARG

Target: PPARG (Peroxisome Proliferator-Activated Receptor gamma (PPARG))

Andere Bezeichnung: PPARG (PPARG Produkte)

Synonyme: PPAR gamma antikoerper, PPARg2 antikoerper, PPARG antikoerper, Nr1c3 antikoerper, PPAR-gamma antikoerper, PPAR-gamma2 antikoerper, PPARgamma antikoerper, PPARgamma2 antikoerper, NR1C3 antikoerper, CIMT1 antikoerper, GLM1 antikoerper, PPARG1 antikoerper, PPARG2 antikoerper, xPPAR-gamma antikoerper, PPAR-GAMMA antikoerper, PPARGAMMA antikoerper, peroxisome proliferator-activated receptor gamma antikoerper, peroxisome proliferator activated receptor gamma antikoerper, peroxisome proliferator activated receptor gamma L homeolog antikoerper, PPARG antikoerper, Pparg antikoerper, pparg.L antikoerper

Hintergrund:

Description: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity).

Gene: PPARG

Molekulargewicht: 57kDa

Gen-ID: 5468

UniProt: P37231

Pathways: MAPK Signalweg, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Endopeptidase Activity, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation