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PIAS1 Antikörper (N-Term)

PIAS1 Reaktivität: Human, Maus, Ratte WB, IHC, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6264195
  • Target Alle PIAS1 Antikörper anzeigen
    PIAS1 (Protein Inhibitor of Activated STAT, 1 (PIAS1))
    Bindungsspezifität
    • 7
    • 7
    • 6
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 42
    • 11
    • 7
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 39
    • 4
    Kaninchen
    Klonalität
    • 40
    • 3
    Polyklonal
    Konjugat
    • 26
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PIAS1 Antikörper ist unkonjugiert
    Applikation
    • 34
    • 19
    • 18
    • 8
    • 4
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    PIAS1 Antibody detects endogenous levels of total PIAS1.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human PIAS1, corresponding to a region within N-terminal amino acids.
    Isotyp
    IgG
    Top Product
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  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    PIAS1 (Protein Inhibitor of Activated STAT, 1 (PIAS1))
    Andere Bezeichnung
    PIAS1 (PIAS1 Produkte)
    Synonyme
    2900068C24Rik antikoerper, Ddxbp1 antikoerper, GBP antikoerper, DDXBP1 antikoerper, GU/RH-II antikoerper, ZMIZ3 antikoerper, ddxbp1 antikoerper, gbp antikoerper, pias antikoerper, pias1-A antikoerper, xPAIS1 antikoerper, xPIAS1 antikoerper, zmiz3 antikoerper, protein inhibitor of activated STAT 1 antikoerper, protein inhibitor of activated STAT, 1 antikoerper, protein inhibitor of activated STAT, 1a antikoerper, protein inhibitor of activated STAT 1 L homeolog antikoerper, PIAS1 antikoerper, Pias1 antikoerper, pias1a antikoerper, pias1.L antikoerper
    Hintergrund

    Description: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (By similarity).

    Gene: PIAS1

    Molekulargewicht
    72kDa
    Gen-ID
    8554
    UniProt
    O75925
    Pathways
    JAK-STAT Signalweg, Interferon-gamma Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation, Hepatitis C
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