IFNAR1 Antikörper (Internal Region)

Produktnummer ABIN6262471

Produktdetails anti-IFNAR1 Antikörper

Target: IFNAR1 (Interferon alpha/beta Receptor 1 (IFNAR1))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IFNAR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Spezifität: IFNAR1 Antibody detects endogenous levels of total IFNAR1.

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human IFNAR1, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu IFNAR1

Target: IFNAR1 (Interferon alpha/beta Receptor 1 (IFNAR1))

Andere Bezeichnung: IFNAR1 (IFNAR1 Produkte)

Synonyme: ifnar1 antikoerper, IFNAR1 antikoerper, CD118 antikoerper, Ifar antikoerper, Ifnar antikoerper, Ifrc antikoerper, Infar antikoerper, AVP antikoerper, IFN-alpha-REC antikoerper, IFNAR antikoerper, IFNBR antikoerper, IFRC antikoerper, IFN-R-1 antikoerper, interferon alpha and beta receptor subunit 1 antikoerper, interferon-alpha/beta receptor alpha chain-like antikoerper, interferon (alpha and beta) receptor 1 antikoerper, interferon alpha/beta receptor 1 antikoerper, IFNAR1 antikoerper, ifnar1 antikoerper, Ifnar1 antikoerper, LOC609830 antikoerper

Hintergrund:

Description: Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:2153461, PubMed:7665574, PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:21854986). Functions in general as heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:21854986). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (PubMed:7665574, PubMed:21854986). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).

Gene: IFNAR1

Molekulargewicht: 63kDa

Gen-ID: 3454

UniProt: P17181

Pathways: JAK-STAT Signalweg, Hepatitis C