HES1 Antikörper (Internal Region)

Produktnummer ABIN6262220

Produktdetails anti-HES1 Antikörper

Target: HES1 (Hes Family bHLH Transcription Factor 1 (HES1))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HES1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Spezifität: HES1 Antibody detects endogenous levels of total HES1.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human HES1, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu HES1

Target: HES1 (Hes Family bHLH Transcription Factor 1 (HES1))

Andere Bezeichnung: HES1 (HES1 Produkte)

Synonyme: HES-1 antikoerper, HHL antikoerper, HRY antikoerper, bHLHb39 antikoerper, Hry antikoerper, HAIRY1 antikoerper, c-hairy1A antikoerper, Xhairy1 antikoerper, hairy1 antikoerper, hes1 antikoerper, Xhairy-1 antikoerper, Xlh1 antikoerper, hes family bHLH transcription factor 1 antikoerper, hairy and enhancer of split 1 (Drosophila) antikoerper, hes family bHLH transcription factor 4 antikoerper, hes family bHLH transcription factor 1 S homeolog antikoerper, hes family bHLH transcription factor 1 L homeolog antikoerper, HES1 antikoerper, Hes1 antikoerper, HES4 antikoerper, hes1.S antikoerper, hes1.L antikoerper

Hintergrund:

Description: Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.

Gene: HES1

Molekulargewicht: 30 kDa

Gen-ID: 3280

UniProt: Q14469

Pathways: DNA Reparatur