HBXIP Antikörper (Internal Region)

Produktnummer ABIN6262158

Produktdetails anti-HBXIP Antikörper

Target: HBXIP (Hepatitis B Virus X-Interacting Protein (HBXIP))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HBXIP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: HBXIP Antibody detects endogenous levels of total HBXIP.

Homologie: Pig,Bovine,Horse,Rabbit,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human HBXIP, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu HBXIP

Target: HBXIP (Hepatitis B Virus X-Interacting Protein (HBXIP))

Andere Bezeichnung: LAMTOR5 (HBXIP Produkte)

Synonyme: HBXIP antikoerper, xip antikoerper, XIP antikoerper, 1110003H18Rik antikoerper, Hbxip antikoerper, late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 antikoerper, Hepatitis B virus X-interacting protein antikoerper, LAMTOR5 antikoerper, xip antikoerper, Lamtor5 antikoerper

Substanzklasse: Viral Protein

Hintergrund:

Description: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.

Gene: LAMTOR5

Molekulargewicht: 22 kDa

Gen-ID: 10542

UniProt: O43504

Pathways: PI3K-Akt Signalweg, Regulation of Cell Size