O3FAR1 Antikörper (Internal Region)

Produktnummer ABIN6262052

Produktdetails anti-O3FAR1 Antikörper

Target: O3FAR1 (omega-3 Fatty Acid Receptor 1 (O3FAR1))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser O3FAR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: GPR120 Antibody detects endogenous levels of total GPR120.

Homologie: Bovine,Horse,Sheep,Rabbit,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human GPR120, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu O3FAR1

Target: O3FAR1 (omega-3 Fatty Acid Receptor 1 (O3FAR1))

Andere Bezeichnung: FFAR4 (O3FAR1 Produkte)

Synonyme: BMIQ10 antikoerper, GPR120 antikoerper, GPR129 antikoerper, GT01 antikoerper, O3FAR1 antikoerper, PGR4 antikoerper, AI552415 antikoerper, Gpr120 antikoerper, Gpr129 antikoerper, KPG_013 antikoerper, O3far1 antikoerper, Pgr4 antikoerper, free fatty acid receptor 4 antikoerper, phosphodiesterase 6C antikoerper, FFAR4 antikoerper, Ffar4 antikoerper, PDE6C antikoerper

Hintergrund:

Description: Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti-inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediate the taste of fatty acids. Mediates FFA-induced inhibition of apoptosis in enteroendocrine cells. May play a role in the regulation of adipocyte development and differentiation.

Gene: FFAR4

Molekulargewicht: 42 kDa

Gen-ID: 338557

UniProt: Q5NUL3

Pathways: Hormone Transport