FZD5 Antikörper (C-Term)

Produktnummer ABIN6261840

Produktdetails anti-FZD5 Antikörper

Target: FZD5 (Frizzled Family Receptor 5 (FZD5))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FZD5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: FZD5 Antibody detects endogenous levels of total FZD5.

Homologie: Pig,Bovine,Sheep,Rabbit,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human FZD5, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu FZD5

Target: FZD5 (Frizzled Family Receptor 5 (FZD5))

Andere Bezeichnung: FZD5 (FZD5 Produkte)

Synonyme: C2orf31 antikoerper, HFZ5 antikoerper, 5330434N09Rik antikoerper, AI427138 antikoerper, Fz-5 antikoerper, Fz5 antikoerper, mFz5 antikoerper, Xfz5 antikoerper, frizzled5 antikoerper, frizzled5a antikoerper, fz5 antikoerper, fzd5-A antikoerper, fz2 antikoerper, fz8c antikoerper, fzd8c antikoerper, zg02 antikoerper, frizzled class receptor 5 antikoerper, frizzled class receptor 5 S homeolog antikoerper, FZD5 antikoerper, Fzd5 antikoerper, fzd5.S antikoerper, fzd5 antikoerper

Hintergrund:

Description: Receptor for Wnt proteins (PubMed:9054360, PubMed:10097073, PubMed:20530549). Can activate WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 (in vitro), the in vivo situation may be different since not all of these are known to be coexpressed (By similarity). In neurons, activation of WNT7A promotes formation of synapses (PubMed:20530549). Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization (By similarity).

Gene: FZD5

Molekulargewicht: 64 kDa

Gen-ID: 7855

UniProt: Q13467

Pathways: WNT Signalweg