EIF3E Antikörper (C-Term)
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- Target Alle EIF3E Antikörper anzeigen
- EIF3E (Eukaryotic Translation Initiation Factor 3 Subunit E (EIF3E))
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Bindungsspezifität
- C-Term
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser EIF3E Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA
- Spezifität
- EIF3E Antibody detects endogenous levels of total EIF3E.
- Homologie
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human EIF3E, corresponding to a region within C-terminal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product EIF3E Primärantikörper
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- Applikationshinweise
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
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- Target
- EIF3E (Eukaryotic Translation Initiation Factor 3 Subunit E (EIF3E))
- Andere Bezeichnung
- EIF3E (EIF3E Produkte)
- Synonyme
- EIF3-P48 antikoerper, EIF3S6 antikoerper, INT6 antikoerper, eIF3-p46 antikoerper, 48kDa antikoerper, Eif3s6 antikoerper, Int6 antikoerper, eIF3-p48 antikoerper, eif3-p48 antikoerper, eif3s6 antikoerper, eif3s6-A antikoerper, eIF3e antikoerper, eIF3-S6 antikoerper, eif3s6-B antikoerper, EIF3SE antikoerper, eif3s6b antikoerper, im:7147439 antikoerper, QtsA-18056 antikoerper, eukaryotic translation initiation factor 3 subunit E antikoerper, eukaryotic translation initiation factor 3, subunit E antikoerper, eukaryotic translation initiation factor 3 subunit E L homeolog antikoerper, eukaryotic translation initiation factor 3 subunit 6 antikoerper, eukaryotic translation initiation factor 3 subunit E S homeolog antikoerper, eukaryotic translation initiation factor 3, subunit E, a antikoerper, Eukaryotic translation initiation factor 3 subunit E antikoerper, eukaryotic translation initiation factor 3, subunit E, b antikoerper, EIF3E antikoerper, Eif3e antikoerper, eif3e antikoerper, eif3e.L antikoerper, LOC692936 antikoerper, eif3e.S antikoerper, eif3ea antikoerper, eif-3.E antikoerper, eif3eb antikoerper, LOC108348260 antikoerper, int6 antikoerper
- Hintergrund
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Description: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). Required for nonsense-mediated mRNA decay (NMD), may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway (PubMed:17468741). May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins (PubMed:17310990, PubMed:17324924).
Gene: EIF3E
- Molekulargewicht
- 52 kDa
- Gen-ID
- 3646
- UniProt
- P60228
- Pathways
- Ribonucleoprotein Complex Subunit Organization, Hepatitis C
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