EIF3E Antikörper (AA 1-445)

Produktnummer ABIN6140059

Produktdetails anti-EIF3E Antikörper

Target: EIF3E (Eukaryotic Translation Initiation Factor 3 Subunit E (EIF3E))

Bindungsspezifität: AA 1-445

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EIF3E Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: MAEYDLTTRI AHFLDRHLVF PLLEFLSVKE IYNEKELLQG KLDLLSDTNM VDFAMDVYKN LYSDDIPHAL REKRTTVVAQ LKQLQAETEP IVKMFEDPET TRQMQSTRDG RMLFDYLADK HGFRQEYLDT LYRYAKFQYE CGNYSGAAEY LYFFRVLVPA TDRNALSSLW GKLASEILMQ NWDAAMEDLT RLKETIDNNS VSSPLQSLQQ RTWLIHWSLF VFFNHPKGRD NIIDLFLYQP QYLNAIQTMC PHILRYLTTA VITNKDVRKR RQVLKDLVKV IQQESYTYKD PITEFVECLY VNFDFDGAQK KLRECESVLV NDFFLVACLE DFIENARLFI FETFCRIHQC ISINMLADKL NMTPEEAERW IVNLIRNARL DAKIDSKLGH VVMGNNAVSP YQQVIEKTKS LSFRSQMLAM NIEKKLNQNS RSEAPNWATQ DSGFY

Kreuzreaktivität: Human, Maus

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-445 of human eIF3e (NP_001559.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu EIF3E

Target: EIF3E (Eukaryotic Translation Initiation Factor 3 Subunit E (EIF3E))

Andere Bezeichnung: EIF3E (EIF3E Produkte)

Synonyme: EIF3-P48 antikoerper, EIF3S6 antikoerper, INT6 antikoerper, eIF3-p46 antikoerper, 48kDa antikoerper, Eif3s6 antikoerper, Int6 antikoerper, eIF3-p48 antikoerper, eif3-p48 antikoerper, eif3s6 antikoerper, eif3s6-A antikoerper, eIF3e antikoerper, eIF3-S6 antikoerper, eif3s6-B antikoerper, EIF3SE antikoerper, eif3s6b antikoerper, im:7147439 antikoerper, QtsA-18056 antikoerper, eukaryotic translation initiation factor 3 subunit E antikoerper, eukaryotic translation initiation factor 3, subunit E antikoerper, eukaryotic translation initiation factor 3 subunit E L homeolog antikoerper, eukaryotic translation initiation factor 3 subunit 6 antikoerper, eukaryotic translation initiation factor 3 subunit E S homeolog antikoerper, eukaryotic translation initiation factor 3, subunit E, a antikoerper, Eukaryotic translation initiation factor 3 subunit E antikoerper, eukaryotic translation initiation factor 3, subunit E, b antikoerper, EIF3E antikoerper, Eif3e antikoerper, eif3e antikoerper, eif3e.L antikoerper, LOC692936 antikoerper, eif3e.S antikoerper, eif3ea antikoerper, eif-3.E antikoerper, eif3eb antikoerper, LOC108348260 antikoerper, int6 antikoerper

Hintergrund: Component of the eukaryotic translation initiation factor 3 (eIF-3 complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC. The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD, may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.,EIF3E,EIF3-P48,EIF3S6,INT6,eIF3-p46,Epigenetics & Nuclear Signaling,EIF3E

Molekulargewicht: 52 kDa

Gen-ID: 3646

UniProt: P60228

Pathways: Ribonucleoprotein Complex Subunit Organization, Hepatitis C