EIF3B Antikörper

Produktnummer ABIN6261481

Produktdetails anti-EIF3B Antikörper

Target: EIF3B (Eukaryotic Translation Initiation Factor 3, Subunit B (EIF3B))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EIF3B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Spezifität: EIF3B Antibody detects endogenous levels of total EIF3B

Kreuzreaktivität: Human, Maus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human EIF3B

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000 IHC 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C.Stable for 12 months from date of receipt

Haltbarkeit: 12 months

Details zu EIF3B

Target: EIF3B (Eukaryotic Translation Initiation Factor 3, Subunit B (EIF3B))

Andere Bezeichnung: EIF3B (EIF3B Produkte)

Synonyme: EIF3-ETA antikoerper, EIF3-P110 antikoerper, EIF3-P116 antikoerper, EIF3S9 antikoerper, PRT1 antikoerper, AL033316 antikoerper, AL033334 antikoerper, AL033369 antikoerper, AW208965 antikoerper, D5Wsu45e antikoerper, Eif3s9 antikoerper, eif3-eta antikoerper, eif3-p110 antikoerper, eif3-p116 antikoerper, eif3s9 antikoerper, prt1 antikoerper, ATEIF3B-2 antikoerper, EIF3B antikoerper, EUKARYOTIC TRANSLATION INITIATION FACTOR 3B antikoerper, F18A17.30 antikoerper, F18A17_30 antikoerper, eukaryotic translation initiation factor 3B-2 antikoerper, DDBDRAFT_0218512 antikoerper, DDBDRAFT_0233929 antikoerper, DDB_0218512 antikoerper, DDB_0233929 antikoerper, eIF-3-eta antikoerper, eif3b antikoerper, wu:fc17c01 antikoerper, GB10123 antikoerper, eIF3b antikoerper, AO090005000892 antikoerper, CaO19.6584 antikoerper, eIF3 p90 antikoerper, eukaryotic translation initiation factor 3 subunit B antikoerper, eukaryotic translation initiation factor 3, subunit B antikoerper, eukaryotic translation initiation factor 3B-2 antikoerper, eukaryotic initiation factor antikoerper, RNA recognition motif-containing protein RRM antikoerper, eukaryotic translation initiation factor 3b antikoerper, eukaryotic translation initiation factor 3 subunit B L homeolog antikoerper, eukaryotic translation initiation factor 3, subunit Ba antikoerper, eukaryotic translation initiation factor 3 subunit 9 antikoerper, translation initiation factor eIF-3 subunit 9 antikoerper, Eukaryotic translation initiation factor 3 subunit B antikoerper, translation initiation factor eIF3 subunit b antikoerper, EIF3B antikoerper, Eif3b antikoerper, eif3b antikoerper, EIF3B-2 antikoerper, eIF3s9 antikoerper, eif3B antikoerper, eif3b.L antikoerper, eif3ba antikoerper, LOC410100 antikoerper, eIF3-S9 antikoerper, AOR_1_1564174 antikoerper, VDBG_02490 antikoerper, PGTG_13070 antikoerper, Tsp_02250 antikoerper, eif-3.B antikoerper, PRT1 antikoerper

Hintergrund:

Description: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:9388245, PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:9388245, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

Gene: EIF3B

Molekulargewicht: 116 kDa

Gen-ID: 8662

UniProt: P55884

Pathways: Ribonucleoprotein Complex Subunit Organization