CX3CL1 Antikörper (Internal Region)

Produktnummer ABIN6261117

Produktdetails anti-CX3CL1 Antikörper

Target: CX3CL1 (Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CX3CL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Spezifität: CX3CL1 Antibody detects endogenous levels of total CX3CL1.

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CX3CL1, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu CX3CL1

Target: CX3CL1 (Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1))

Andere Bezeichnung: CX3CL1 (CX3CL1 Produkte)

Synonyme: ABCD3 antikoerper, CX3CL1 antikoerper, DKFZp459K117 antikoerper, Cx3c antikoerper, Scyd1 antikoerper, ABCD-3 antikoerper, C3Xkine antikoerper, CXC3 antikoerper, CXC3C antikoerper, NTN antikoerper, NTT antikoerper, SCYD1 antikoerper, fractalkine antikoerper, neurotactin antikoerper, AB030188 antikoerper, AI848747 antikoerper, CX3C antikoerper, Cxc3 antikoerper, D8Bwg0439e antikoerper, ATP binding cassette subfamily D member 3 antikoerper, C-X3-C motif chemokine ligand 1 antikoerper, chemokine (C-X3-C motif) ligand 1 antikoerper, ABCD3 antikoerper, CX3CL1 antikoerper, Cx3cl1 antikoerper, Abcd3 antikoerper

Hintergrund:

Description: Acts as a ligand for both CX3CR1 and integrins. Binds to CX3CR1 (PubMed:23125415, PubMed:9931005, PubMed:21829356). Binds to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1 (PubMed:23125415, PubMed:24789099). The soluble form is chemotactic for T-cells and monocytes and not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium (PubMed:9024663, PubMed:9177350).

Gene: CX3CL1

Molekulargewicht: 90-100 kDa

Gen-ID: 6376

UniProt: P78423

Pathways: Synaptic Membrane