CDC34 Antikörper (Internal Region)

Produktnummer ABIN6260683

Produktdetails anti-CDC34 Antikörper

Target: CDC34 (Cell Division Cycle 34 (CDC34))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDC34 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: CDC34 Antibody detects endogenous levels of total CDC34.

Homologie: Pig,Bovine,Sheep,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CDC34, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu CDC34

Target: CDC34 (Cell Division Cycle 34 (CDC34))

Andere Bezeichnung: CDC34 (CDC34 Produkte)

Synonyme: E2-CDC34 antikoerper, UBC3 antikoerper, UBCH3 antikoerper, UBE2R1 antikoerper, AI327276 antikoerper, e2-cdc34 antikoerper, ubc3 antikoerper, ube2r1 antikoerper, CDC34 antikoerper, DNA6 antikoerper, Ube2r2 antikoerper, zgc:55452 antikoerper, fb34h09 antikoerper, wu:fb34h09 antikoerper, wu:fe17e09 antikoerper, zgc:91847 antikoerper, cell division cycle 34 antikoerper, cell division cycle 34 L homeolog antikoerper, SCF E2 ubiquitin-protein ligase catalytic subunit CDC34 antikoerper, SCF E2 ubiquitin-protein ligase catalytic subunit antikoerper, cell division cycle 34 homolog (S. cerevisiae) a antikoerper, cell division cycle 34 homolog (S. cerevisiae) b antikoerper, CDC34 antikoerper, Cdc34 antikoerper, cdc34.L antikoerper, cdc34 antikoerper, cdc34a antikoerper, cdc34b antikoerper

Hintergrund:

Description: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:22496338). Cooperates with the E2 UBCH5C and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Cooperates with the SCF(SKP2) E3 ligase complex to regulate cell proliferation through ubiquitination and degradation of MYBL2 and KIP1. Involved in ubiquitin conjugation and degradation of CREM isoform ICERIIgamma and ATF15 resulting in abrogation of ICERIIgamma- and ATF5-mediated repression of cAMP-induced transcription during both meiotic and mitotic cell cycles. Involved in the regulation of the cell cycle G2/M phase through its targeting of the WEE1 kinase for ubiquitination and degradation. Also involved in the degradation of beta-catenin. Is target of human herpes virus 1 protein ICP0, leading to ICP0-dependent dynamic interaction with proteasomes (PubMed:10329681, PubMed:10373550, PubMed:10871850, PubMed:11675391, PubMed:12037680, PubMed:15652359, PubMed:17461777, PubMed:17698585, PubMed:19112177, PubMed:19126550, PubMed:19945379, PubMed:20061386, PubMed:20347421).

Gene: CDC34

Molekulargewicht: 26 kDa

Gen-ID: 997

UniProt: P49427