BRSK2 Antikörper (Internal Region)

Produktnummer ABIN6260317

Produktdetails anti-BRSK2 Antikörper

Target: BRSK2 (BR serine/threonine Kinase 2 (BRSK2))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BRSK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: BRSK2 Antibody detects endogenous levels of total BRSK2.

Homologie: Pig,Bovine,Horse,Dog,Chicken

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human BRSK2, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu BRSK2

Target: BRSK2 (BR serine/threonine Kinase 2 (BRSK2))

Andere Bezeichnung: BRSK2 (BRSK2 Produkte)

Synonyme: C11orf7 antikoerper, PEN11B antikoerper, SAD1 antikoerper, SADA antikoerper, STK29 antikoerper, BRSK2 antikoerper, 4833424K13Rik antikoerper, SAD-A antikoerper, BR serine/threonine kinase 2 antikoerper, BRSK2 antikoerper, Brsk2 antikoerper

Hintergrund:

Description: Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress.

Gene: BRSK2

Molekulargewicht: 82 kDa

Gen-ID: 9024

UniProt: Q8IWQ3