MOB1A Antikörper (Internal Region)

Produktnummer ABIN6259071

Produktdetails anti-MOB1A Antikörper

Target: MOB1A (MOBKL1B) (MOB1, Mps One Binder Kinase Activator-Like 1B (MOBKL1B))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MOB1A Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: MOBKL1B Antibody detects endogenous levels of total MOBKL1B.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human MOBKL1B, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu MOB1A

Target: MOB1A (MOBKL1B) (MOB1, Mps One Binder Kinase Activator-Like 1B (MOBKL1B))

Andere Bezeichnung: MOB1A (MOBKL1B Produkte)

Synonyme: mob1 antikoerper, mob4b antikoerper, MOB1A antikoerper, MOBK1B antikoerper, MOB1 antikoerper, mats1 antikoerper, mobk1b antikoerper, mobkl1b antikoerper, MOBKL1B antikoerper, wu:fv69d04 antikoerper, zgc:56189 antikoerper, C2orf6 antikoerper, MATS1 antikoerper, Mob4B antikoerper, 4022402H07Rik antikoerper, MOB4B antikoerper, Mobk1b antikoerper, Mobkl1b antikoerper, MOB kinase activator 1A L homeolog antikoerper, MOB kinase activator 1A antikoerper, MOB kinase activator 1A pseudogene antikoerper, mob1a.L antikoerper, MOB1A antikoerper, mob1a antikoerper, LOC712156 antikoerper, Mob1a antikoerper

Hintergrund:

Description: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38.

Gene: MOB1A

Molekulargewicht: 25 kDa

Gen-ID: 55233

UniProt: Q9H8S9