UBE2D3 Antikörper

Produktnummer ABIN6258377

Produktdetails anti-UBE2D3 Antikörper

Target: UBE2D3 (Ubiquitin-Conjugating Enzyme E2D 3 (UBE2D3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UBE2D3 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Spezifität: UBE2D3 antibody detects endogenous levels of total UBE2D3

Kreuzreaktivität: Human, Maus, Ratte (Rattus)

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Details zu UBE2D3

Target: UBE2D3 (Ubiquitin-Conjugating Enzyme E2D 3 (UBE2D3))

Andere Bezeichnung: UBE2D3 (UBE2D3 Produkte)

Synonyme: E2(17)KB3 antikoerper, UBC4/5 antikoerper, UBCH5C antikoerper, eff antikoerper, fb36f02 antikoerper, wu:fb36f02 antikoerper, zgc:56340 antikoerper, 1100001F19Rik antikoerper, 9430029A22Rik antikoerper, AA414951 antikoerper, UBE2D3P antikoerper, Xubc4 antikoerper, e2(17)kb3 antikoerper, ubc4/5 antikoerper, ubch5c antikoerper, ube2d3.1 antikoerper, ube2d2 antikoerper, xubc4 antikoerper, wu:fj13d01 antikoerper, zgc:73200 antikoerper, ubiquitin conjugating enzyme E2 D3 antikoerper, ubiquitin-conjugating enzyme E2D 3 antikoerper, ubiquitin conjugating enzyme E2 D3 L homeolog antikoerper, ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast), like antikoerper, UBE2D3 antikoerper, ube2d3 antikoerper, Ube2d3 antikoerper, LOC100223566 antikoerper, ube2d3.L antikoerper, ube2d2l antikoerper

Hintergrund:

Description: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction.

Gene: UBE2D3

Molekulargewicht: 17 kDa

Gen-ID: 7323

UniProt: P61077

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades