PIP5K1C Antikörper (Internal Region)

Produktnummer ABIN6258304

Produktdetails anti-PIP5K1C Antikörper

Target: PIP5K1C (Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, gamma (PIP5K1C))

Bindungsspezifität: Internal Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIP5K1C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Spezifität: PIP5K1C Antibody detects endogenous levels of total PIP5K1C.

Homologie: Pig,Bovine,Sheep,Dog,Chicken

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human PIP5K1C, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu PIP5K1C

Target: PIP5K1C (Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, gamma (PIP5K1C))

Andere Bezeichnung: PIP5K1C (PIP5K1C Produkte)

Synonyme: LCCS3 antikoerper, PIP5K-GAMMA antikoerper, PIP5Kgamma antikoerper, PIPKIg_v4 antikoerper, MGC130766 antikoerper, PIP5K1C antikoerper, AI115456 antikoerper, AI835305 antikoerper, Pip5kIgamma antikoerper, phosphatidylinositol-4-phosphate 5-kinase type 1 gamma antikoerper, phosphatidylinositol-4-phosphate 5-kinase, type I, gamma S homeolog antikoerper, phosphatidylinositol-4-phosphate 5-kinase, type I, gamma antikoerper, phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma antikoerper, PIP5K1C antikoerper, Pip5k1c antikoerper, pip5k1c.S antikoerper, pip5k1c antikoerper

Hintergrund:

Description: Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as vesicle mediated transport, cell adhesion, cell polarization and cell migration. Together with PIP5K1A is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle attachment by generating the pool of PtdIns(4,5)P2 that induces controlled actin depolymerization to facilitate Fc-gamma-R clustering. Mediates RAC1-dependent reorganization of actin filaments. Required for synaptic vesicle transport. Controls the plasma membrane pool of PtdIns(4,5)P2 implicated in synaptic vesicle endocytosis and exocytosis. Plays a role in endocytosis mediated by clathrin and AP-2 (adaptor protein complex 2). Required for clathrin-coated pits assembly at the synapse. Participates in cell junction assembly. Modulates adherens junctions formation by facilitating CDH1 trafficking. Required for focal adhesion dynamics. Modulates the targeting of talins (TLN1 and TLN2) to the plasma membrane and their efficient assembly into focal adhesions. Regulates the interaction between talins (TLN1 and TLN2) and beta-integrins. Required for uropodium formation and retraction of the cell rear during directed migration. Has a role in growth factor- stimulated directional cell migration and adhesion. Required for talin assembly into nascent adhesions forming at the leading edge toward the direction of the growth factor. Negative regulator of T-cell activation and adhesion. Negatively regulates integrin alpha-L/beta-2 (LFA-1) polarization and adhesion induced by T-cell receptor. Together with PIP5K1A has a role during embryogenesis and together with PIP5K1B may have a role immediately after birth.

Gene: PIP5K1C

Molekulargewicht: 80 kDa

Gen-ID: 23396

UniProt: O60331

Pathways: PI3K-Akt Signalweg, Inositol Metabolic Process, Cell-Cell Junction Organization, Maintenance of Protein Location, Synaptic Vesicle Exocytosis