C-JUN Antikörper (pSer73)
Kurzübersicht für C-JUN Antikörper (pSer73) (ABIN6255488)
Target
Alle C-JUN (JUN) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
 - pSer73
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Spezifität
 - Phospho-c-Jun (Ser73) Antibody detects endogenous levels of c-Jun only when phosphorylated at Serine 73
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Kreuzreaktivität
 - Human, Maus, Ratte (Rattus), Zebrafisch (Danio rerio)
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Aufreinigung
 - The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
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Immunogen
 - A synthesized peptide derived from human c-Jun around the phosphorylation site of Serine 73
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Isotyp
 - IgG
 
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Applikationshinweise
 - WB 1:500-1:2000 IHC 1:50-1:200, IF/ICC 1:100-1:500
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Beschränkungen
 - Nur für Forschungszwecke einsetzbar
 
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Format
 - Liquid
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Konzentration
 - 1 mg/mL
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Buffer
 - Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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Konservierungsmittel
 - Sodium azide
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Vorsichtsmaßnahmen
 - This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
 - -20 °C
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Informationen zur Lagerung
 - Store at -20 °C.Stable for 12 months from date of receipt
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Haltbarkeit
 - 12 months
 
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                                            : "MFAP5 promotes tumor progression and bone metastasis by regulating ERK/MMP signaling pathways in breast cancer."    in: Biochemical and biophysical research communications, Vol. 498, Issue 3, pp. 495-501, (2018)         (PubMed).        
 
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                                            : "MFAP5 promotes tumor progression and bone metastasis by regulating ERK/MMP signaling pathways in breast cancer."    in: Biochemical and biophysical research communications, Vol. 498, Issue 3, pp. 495-501, (2018)         (PubMed).        
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- C-JUN (JUN) (Jun Proto-Oncogene (JUN))
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Andere Bezeichnung
 - c-Jun
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Hintergrund
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Description: Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).
Gene: JUN
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Molekulargewicht
 - 37kDa
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Gen-ID
 - 3725
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UniProt
 - P05412, P17535
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Pathways
 - MAPK Signalweg, RTK Signalweg, WNT Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Skeletal Muscle Fiber Development, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Autophagie, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling, S100 Proteine
 
Target
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