TGF-beta Antikörper

Produktnummer ABIN6252537

Produktdetails anti-TGF-beta Antikörper

Target: TGF-beta (TGFb)

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Hamster, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TGF-beta Antikörper ist unkonjugiert

Applikation: Neutralization (Neut)

Aufreinigung: Protein G affinity chromatography

Immunogen: Bovine TGF-beta2 protein was used as the immunogen for the TGF-beta antibody.

Klon: 1D11-16-8

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Functional Activity: Cytokine Neutralization (Order SAF formulation)

Optimal dilution of the TGF-beta antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: PBS with 0.1 mg/mL BSA and 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot and Store at -20C. Avoid freez-thaw cycles.

Details zu TGF-beta

Target: TGF-beta (TGFb)

Andere Bezeichnung: TGF-beta (TGFb Produkte)

Synonyme: CED antikoerper, DPD1 antikoerper, LAP antikoerper, TGFB antikoerper, TGFbeta antikoerper, TGF-beta antikoerper, TGF-BETA-1 antikoerper, TGF-beta1 antikoerper, TGFbeta1 antikoerper, Tgfb antikoerper, Tgfb-1 antikoerper, transforming growth factor beta 1 antikoerper, transforming growth factor beta-1 antikoerper, transforming growth factor, beta 1 antikoerper, TGFB1 antikoerper, Tgfb1 antikoerper

Hintergrund: This mAb recognizes TGF beta 1, 2 and 3. Three TGFbs have been identified in mammals. TGFb1, TGFb2 and TGFb3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGFb requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGFb3 protein has approximately 80 % identity to the mature region of both TGFb1 and TGFb2. However, the NH2 terminals or precursor regions of their molecules share only 27 % sequence identity. TGFb's inhibit the growth of epithelial cells and stimulate the growth of mesenchymal cells.

Gen-ID: 7040, 7043, 7042

UniProt: P01137, P10600, P61812

Pathways: EGFR Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Stem Cell Maintenance, Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus