XRCC5 Antikörper

Produktnummer ABIN6241745

Produktdetails anti-XRCC5 Antikörper

Target: XRCC5 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser XRCC5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Immunogen: Recombinant Protein

Anwendungsinformationen

Applikationshinweise: IP: 1:500. WB: 1:1000. ICC: 1:400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Lagerung: 4 °C,-20 °C

Details zu XRCC5

Target: XRCC5 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5))

Andere Bezeichnung: Ku80 (XRCC5 Produkte)

Synonyme: AI314015 antikoerper, Ku80 antikoerper, Ku86 antikoerper, Kup80 antikoerper, KARP-1 antikoerper, KARP1 antikoerper, KU80 antikoerper, KUB2 antikoerper, NFIV antikoerper, xrcc5-a antikoerper, XRCC5 antikoerper, X-ray repair cross complementing 5 antikoerper, X-ray repair complementing defective repair in Chinese hamster cells 5 antikoerper, X-ray repair complementing defective repair in Chinese hamster cells 5 L homeolog antikoerper, XRCC5 antikoerper, Xrcc5 antikoerper, xrcc5.L antikoerper

Hintergrund: Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. In association with NAA15, the XRCC5/6 dimer binds to the osteocalcin promoter and activates osteocalcin expression. The XRCC5/6 dimer probably also acts as a 5'- deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription.

UniProt: P13010

Pathways: DNA Reparatur