CRTC2 Antikörper (C-Term)

Produktnummer ABIN615884

Produktdetails anti-CRTC2 Antikörper

Target: CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Schwein, Hund, Rind (Kuh)

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser CRTC2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequenz: C-DPAVEDSFRS DRLQ

Spezifität: Recognizes TORC2

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Rat, Dog, Pig, Cow.
Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography

Immunogen: Peptide with sequence from the C Terminus of the protein sequence according to NP_083157.1. Genename: CRTC2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu CRTC2

Target: CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))

Andere Bezeichnung: CRTC2 / TORC2 (CRTC2 Produkte)

Synonyme: CRTC2 antikoerper, TORC-2 antikoerper, TORC2 antikoerper, 4632407F12Rik antikoerper, Torc2 antikoerper, mTORC2 antikoerper, RGD1308903 antikoerper, CREB regulated transcription coactivator 2 antikoerper, CRTC2 antikoerper, Crtc2 antikoerper

Hintergrund: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). Most abundantly expressed in the thymus. Present in both B and T lymphocytes. Highly expressed in HEK293T cells and in insulinomas. High levels also in spleen, ovary, muscle and lung, with highest levels in muscle. Lower levels found in brain, colon, heart, kidney, prostate, small intestine and stomach. Weak expression in liver and pancreas.Synonyms: CREB-regulated transcription coactivator 2, TORC-2, Transducer of CREB protein 2, Transducer of regulated cAMP response element-binding protein 2

Molekulargewicht: 73.2kDa (NP_083157.1).

Gen-ID: 74343

NCBI Accession: NP_083157

UniProt: Q3U182

Pathways: AMPK Signaling, Carbohydrate Homeostasis