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CRTC2 Produkte

(CREB Regulated Transcription Coactivator 2 (CRTC2))

Kategorien

This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2010].

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Ausgewählte CRTC2 Kategorien

CRTC2 Antikörper

High quality antibodies with extensive validation data.

CRTC2 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene CRTC2 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human, Rat
Applikation WB, ELISA, IF, FACS
Validierungen
  • (6)
Kat. Nr. ABIN5539499
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human, Monkey
Applikation WB, ELISA, IHC, FACS, ICC
Validierungen
  • (3)
  • (4)
Kat. Nr. ABIN969067
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human, Mouse
Applikation WB, ELISA, FACS
Validierungen
  • (4)
  • (2)
Kat. Nr. ABIN745988
Menge 100 μL
Datenblatt Datenblatt

Empfohlene CRTC2 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6966120
Menge 96 tests
Datenblatt Datenblatt

Empfohlene CRTC2 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1350407
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1350406
Menge 25 μg
Datenblatt Datenblatt
Reaktivität Human
Source Insect Cells
Validierungen
  • (1)
Kat. Nr. ABIN3092005
Menge 1 mg
Datenblatt Datenblatt

Neueste Publikationen zu unseren CRTC2 Produkten

Slocum, Skoko, Wakabayashi, Aja, Yamamoto, Kensler, Chartoumpekis: "Keap1/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic and lipogenic program in mice on a high-fat diet." in: Archives of biochemistry and biophysics, Vol. 591, pp. 57-65, (2016) (PubMed).

Seok, Fu, Choi, Li, Zhu, Kumar, Sun, Yoon, Kang, Zhong, Ma, Kemper, Kemper: "Transcriptional regulation of autophagy by an FXR-CREB axis." in: Nature, Vol. 516, Issue 7529, pp. 108-11, (2015) (PubMed).

Tian, Zhao, Sun, Zhi, Cheng, Zhou, Hu: "CRTC2 enhances HBV transcription and replication by inducing PGC1? expression." in: Virology journal, Vol. 11, Issue 1, pp. 30, (2014) (PubMed).

Cicerchi, Li, Kratzer, Garcia, Roncal-Jimenez, Tanabe, Hunter, Rivard, Sautin, Gaucher, Johnson, Lanaspa: "Uric acid-dependent inhibition of AMP kinase induces hepatic glucose production in diabetes and starvation: evolutionary implications of the uricase loss in hominids." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 28, Issue 8, pp. 3339-50, (2014) (PubMed).

Jeanneteau, Lambert, Ismaili, Bath, Lee, Garabedian, Chao: "BDNF and glucocorticoids regulate corticotrophin-releasing hormone (CRH) homeostasis in the hypothalamus." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 4, pp. 1305-10, (2012) (PubMed).

Liu, Coello, Grinevich, Aguilera: "Involvement of transducer of regulated cAMP response element-binding protein activity on corticotropin releasing hormone transcription." in: Endocrinology, Vol. 151, Issue 3, pp. 1109-18, (2010) (PubMed).

Murata, Sato, Nakayama, Kudoh, Iwahori, Isomura, Tajima, Hishiki, Ohshima, Hijikata, Shimotohno, Tsurumi: "TORC2, a coactivator of cAMP-response element-binding protein, promotes Epstein-Barr virus reactivation from latency through interaction with viral BZLF1 protein." in: The Journal of biological chemistry, Vol. 284, Issue 12, pp. 8033-41, (2009) (PubMed).

Yuan, Liu, Wu, McGonagill, Keller, Galle, Meier et al.: "Breaking human cytomegalovirus major immediate-early gene silence by vasoactive intestinal peptide stimulation of the protein kinase A-CREB-TORC2 signaling cascade in human pluripotent embryonal ..." in: Journal of virology, Vol. 83, Issue 13, pp. 6391-403, (2009) (PubMed).

Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).

Dentin, Liu, Koo, Hedrick, Vargas, Heredia, Yates, Montminy: "Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2." in: Nature, Vol. 449, Issue 7160, pp. 366-9, (2007) (PubMed).

Synonyme und alternative Namen zu CRTC2

CREB regulated transcription coactivator 2 (CRTC2), CREB regulated transcription coactivator 2 (Crtc2), 4632407F12Rik, CRTC2, mTORC2, RGD1308903, TORC-2, TORC2, Torc2

Bezeichner auf Proteinebene für CRTC2

  • CREB regulated transcription coactivator 2
  • CREB-regulated transcription coactivator 2
  • CREB-regulated transcription coactivator 2-like
  • transducer of regulated cAMP response element-binding protein (CREB) 2
  • TORC-2
  • transducer of CREB protein 2
  • transducer of regulated cAMP response element-binding protein 2
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