Transglutaminase 2 Antikörper (CF®488A)
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- Target Alle Transglutaminase 2 (TGM2) Antikörper anzeigen
- Transglutaminase 2 (TGM2) (Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM2))
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Reaktivität
- Human, Maus, Ratte, Affe, Kaninchen
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser Transglutaminase 2 Antikörper ist konjugiert mit CF®488A
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Applikation
- Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Verwendungszweck
- Mouse Monoclonal anti-Transglutaminase-II (TGM2/419), CF488A Conjugate
- Produktmerkmale
- This antibody recognizes a 77-85 kDa protein, identified as cellular or tissue transglutaminase II (TGase II). Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. The identification of transglutaminase as the main antigen of endomysium antibodies allows a new diagnostic approach to celiac disease (CD), a genetic, immunologically mediated small bowel enteropathy that causes malabsorption. TGase II is implicated in programmed cell death, signal transduction, drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract formation, and wound healing. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Immunogen
- Recombinant full-length human TGM2 protein
- Klon
- TGM2-419
- Isotyp
- IgG2a kappa
- Top Product
- Discover our top product TGM2 Primärantikörper
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- Applikationshinweise
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Immunohistology formalin-fixed 0.5-1 μg/mL
- Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes
- Immunofluorescence 0.5-1 μg/mL
- Flow Cytometry 0.5-1 μg/million cells/0.1 mL
- Optimal dilution for a specific application should be determined by user
- Kommentare
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HUVEC Cells. Endothelial cells in placenta, liver, brain, or breast carcinoma. Smooth muscle cells of any origin (e.g. intestine)
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 100 μg/mL
- Buffer
- PBS/0.1 % BSA/0.05 % azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Protect from light
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- Target
- Transglutaminase 2 (TGM2) (Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM2))
- Andere Bezeichnung
- Transglutaminase-II (TGM2 Produkte)
- Synonyme
- G-ALPHA-h antikoerper, GNAH antikoerper, TG2 antikoerper, TGC antikoerper, tgm2 antikoerper, zgc:101081 antikoerper, TgaseII antikoerper, TGM2 antikoerper, fc12b04 antikoerper, wu:fc12b04 antikoerper, zgc:136700 antikoerper, TGL2 antikoerper, G[a]h antikoerper, TGase2 antikoerper, tTG antikoerper, tTGas antikoerper, transglutaminase 2 antikoerper, transglutaminase 2, C polypeptide A antikoerper, transglutaminase 2b antikoerper, transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) antikoerper, transglutaminase 2, C polypeptide antikoerper, TGM2 antikoerper, tgm2a antikoerper, Tgm2 antikoerper, tgm2b antikoerper
- Molekulargewicht
- 77-85 kDa
- Gen-ID
- 7052, 517033
- UniProt
- P21980
- Pathways
- Tube Formation, Thromboxane A2 Receptor Signaling
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