TSHR, A Chain Antikörper (CF®488A)

Produktnummer ABIN6154159

Produktdetails anti-TSHR, A Chain Antikörper (CF®488A)

Target: TSHR, A Chain (Thyroid Stimulating Hormone Receptor, A Chain (TSHR, A Chain))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TSHR, A Chain Antikörper ist konjugiert mit CF®488A

Applikation: Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC)

Verwendungszweck: Mouse Monoclonal anti-TSH Receptor, A chain (TSHRA/1402), CF488A Conjugate

Produktmerkmale: Thyroid-stimulating hormone (TSH, also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Graves disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: A-Chain protein|Recombinant human TSHR

Klon: TSHRA-1402

Isotyp: IgG kappa

Anwendungsinformationen

Applikationshinweise: Immunohistology (formalin) 0.5-1 μg/mL

• Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Tris with 1 mM EDTA
•   pH 9.0
• or 10 mM citrate buffer
•   pH 6.0
• for 10-20 min followed by cooling at RT for 20 min
• Flow Cytometry 0.5-1 μg/million cells/0.1 mL
• Immunofluorescence 1-2 μg/mL
• Optimal dilution for a specific application should be determined by user

Kommentare:

293T Cells. Thyroid gland

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 100 μg/mL

Buffer: PBS/0.1 % BSA/0.05 % azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from light

Details zu TSHR, A Chain

Target: TSHR, A Chain (Thyroid Stimulating Hormone Receptor, A Chain (TSHR, A Chain))

Andere Bezeichnung: TSH Receptor, A chain (TSHR, A Chain Produkte)

Hintergrund: CHNG1, hTSHRI, LGR3, Thyroid-stimulating hormone receptor, Thyrotropin receptor, Thyrotropin receptor I, TSHR

Molekulargewicht: 62 kDa

Gen-ID: 7253, 160411

UniProt: P16473