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TSHR, A Chain Antikörper

TSHR, A Chain Reaktivität: Human FACS, IF, IHC (p) Wirt: Maus Monoclonal TSHRA-1402 unconjugated
Produktnummer ABIN4949908
  • Target Alle TSHR, A Chain Produkte
    TSHR, A Chain (Thyroid Stimulating Hormone Receptor, A Chain (TSHR, A Chain))
    Reaktivität
    Human
    Wirt
    • 17
    Maus
    Klonalität
    • 17
    Monoklonal
    Konjugat
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser TSHR, A Chain Antikörper ist unkonjugiert
    Applikation
    • 17
    • 17
    • 7
    • 7
    • 3
    Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    Protein G affinity chromatography
    Immunogen
    Recombinant human TSH Receptor alpha chain protein was used as the immunogen for this TSHR antibody.
    Klon
    TSHRA-1402
    Isotyp
    IgG
  • Applikationshinweise
    The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the TSHR antibody to be titered up or down for optimal performance.\. FACS: 0.5-1 μg/10^6 cells in 0.1ml,IF: 1-2 μg/mL,IHC (FFPE): 0.5-1 μg/mL
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    1 mg/mL in 1X PBS, BSA free, sodium azide free
    Konservierungsmittel
    Azide free
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store the TSHR antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
  • Target
    TSHR, A Chain (Thyroid Stimulating Hormone Receptor, A Chain (TSHR, A Chain))
    Andere Bezeichnung
    Thyroid Stimulating Hormone Receptor / TSHR (alpha chain) (TSHR, A Chain Produkte)
    Hintergrund
    Thyroid-stimulating hormone (TSH, also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Graves disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits.
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