Fascin Antikörper (CF®640R)

Produktnummer ABIN6152546

Produktdetails anti-Fascin Antikörper (CF®640R)

Target: Fascin (FSCN1)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Fascin Antikörper ist konjugiert mit CF®640R

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Verwendungszweck: Mouse Monoclonal anti-Fascin-1 (FSCN1/417), CF640R Conjugate

Produktmerkmale: This antibody recognizes a protein of 55 kDa, which is identified as fascin-1. Its actin binding ability is regulated by phosphorylation. Antibody to fascin-1 is a very sensitive marker for Reed-Sternberg cells and variants in nodular sclerosis, mixed cellularity, and lymphocyte depletion Hodgkin's disease. It is uniformly negative in lymphoid cells, plasma cells, and myeloid cells. Fascin-1 is also expressed in dendritic cells. This marker may be helpful to distinguish between Hodgkin lymphoma and non-Hodgkin lymphoma in difficult cases. Also, the lack of expression of fascin-1 in the neoplastic follicles in follicular lymphoma may be helpful in distinguishing these lymphomas from reactive follicular hyperplasia in which the number of follicular dendritic cells is normal or increased. Antibody to fascin-1 has been suggested as a prognostic marker in neuroendocrine neoplasms of the lung as well as in ovarian cancer. Fascin-1 expression may be induced by Epstein-Barr virus (EBV) infection of B cells with the possibility that viral induction of fascin in lymphoid or other cell types must also be considered in EBV-positive cases. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Full length recombinant human FSCN1 protein

Klon: FSCN1-417

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Immunohistology formalin-fixed 0.5-1 μg/mL

• Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer,  pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes
• Flow Cytometry 0.5-1 μg/million cells/0.1 mL
• Immunofluorescence 1-2 μg/mL
• Western blotting 0.5-1.0 μg/mL
• Optimal dilution for a specific application should be determined by user

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 100 μg/mL

Buffer: PBS/0.1 % BSA/0.05 % azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from light

Details zu Fascin

Target: Fascin (FSCN1)

Andere Bezeichnung: Fascin-1 (FSCN1 Produkte)

Synonyme: CG15331 antikoerper, CG1536 antikoerper, CG32858 antikoerper, Dmel\\CG32858 antikoerper, SN antikoerper, Sn antikoerper, fs(1)A1057 antikoerper, fs(1)K1421 antikoerper, fs(1)K418 antikoerper, fs(1)K473 antikoerper, fs(1)K743 antikoerper, fs(1)M45 antikoerper, p55 antikoerper, snl antikoerper, MGC75811 antikoerper, fscn1 antikoerper, sb:cb589 antikoerper, zgc:153632 antikoerper, AI663989 antikoerper, Fan1 antikoerper, fascin-1 antikoerper, Fascin antikoerper, fscn antikoerper, FAN1 antikoerper, HSN antikoerper, SNL antikoerper, fascin antikoerper, singed antikoerper, fascin actin-bundling protein 1 antikoerper, fascin actin-bundling protein 1a antikoerper, fascin actin-bundling protein 1 L homeolog antikoerper, sn antikoerper, fscn1 antikoerper, fscn1a antikoerper, Fscn1 antikoerper, fscn1.L antikoerper, FSCN1 antikoerper

Hintergrund: 55  kDa actin-bundling protein, FAN1, Fascin homolog 1, Fascin1, FSCN1, HSN, p55, Singed (Drosophila) like (sea urchin fascin homolog like), SNL

Molekulargewicht: 55 kDa

Gen-ID: 6624, 118400

UniProt: Q16658