Lamin A/C Antikörper (N-Term)

Produktnummer ABIN615033

Produktdetails anti-Lamin A/C Antikörper

Target: Lamin A/C (LMNA)

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Lamin A/C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody reacts strongly in immunoblotting with fragments corresponding to peptide 319-572aa of Lamin C. When tested against nuclear protein extracts from HeLa cells it reacts with a single band migrating at 65 kDa. Stains Lamin C from human, mouse and rat material.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography

Immunogen: Lamin C antibody was raised against a peptide made from the last 8 amino acids of Lamin C, including an N-terminal lysine as a linker (KHHVSGSRR), coupled to KLH

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Lamin A/C

Target: Lamin A/C (LMNA)

Andere Bezeichnung: Lamin-A/C (LMNA) (LMNA Produkte)

Synonyme: CDCD1 antikoerper, CDDC antikoerper, CMD1A antikoerper, CMT2B1 antikoerper, EMD2 antikoerper, FPL antikoerper, FPLD antikoerper, FPLD2 antikoerper, HGPS antikoerper, IDC antikoerper, LDP1 antikoerper, LFP antikoerper, LGMD1B antikoerper, LMN1 antikoerper, LMNC antikoerper, LMNL1 antikoerper, PRO1 antikoerper, Dhe antikoerper, 2459 antikoerper, 74/76 antikoerper, CG6944 antikoerper, D5 antikoerper, DM[[O]] antikoerper, Dm antikoerper, Dm(0) antikoerper, Dm0 antikoerper, Dm1 antikoerper, Dm2 antikoerper, DmLamin antikoerper, DmO antikoerper, Dm[[0]] antikoerper, Dm[[1]] antikoerper, Dm[[2]] antikoerper, Dm[[mit]] antikoerper, Dm[[o]] antikoerper, Dmel\\CG6944 antikoerper, Dmo antikoerper, LAM antikoerper, Lam Dm[[0]] antikoerper, Lam(Dm0) antikoerper, LamDm[[0]] antikoerper, LamDm[[o]] antikoerper, Lam[[Dm0]] antikoerper, Lamin Dm[[0]] antikoerper, jf27 antikoerper, l(2)04643 antikoerper, l(2)25Ec antikoerper, l(2)gdh-7 antikoerper, l(2)gdh7 antikoerper, l(2)jf27 antikoerper, lam antikoerper, lamDm0 antikoerper, lamDm[[0]] antikoerper, lamin antikoerper, lamin Dm0 antikoerper, lamin Dm[[0]] antikoerper, misg antikoerper, nlam antikoerper, cb948 antikoerper, fk66d12 antikoerper, wu:fk66d12 antikoerper, lmna-A antikoerper, fpl antikoerper, idc antikoerper, lfp antikoerper, cddc antikoerper, emd2 antikoerper, fpld antikoerper, hgps antikoerper, ldp1 antikoerper, lmn1 antikoerper, lmnc antikoerper, pro1 antikoerper, cdcd1 antikoerper, cmd1a antikoerper, cmt2b1 antikoerper, lgmd1b antikoerper, Lamin-A antikoerper, lamin-L(III)-like antikoerper, lamin A/C antikoerper, lamin A antikoerper, Lamin antikoerper, lamin A/C L homeolog antikoerper, lamin-L(III)-like antikoerper, LMNA antikoerper, Lmna antikoerper, Lam antikoerper, lmna antikoerper, lmna.L antikoerper, LMINA antikoerper

Hintergrund: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Play an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.Synonyms: 70 kDa Lamin, LMN1, LMNA, Lamin A, Lamin A + C, Lamin-A/C, NY-REN-32, NYREN32, Nuclear Envelope Marker, Renal carcinoma antigen NY-REN-32

Gen-ID: 4000

NCBI Accession: NP_005563

UniProt: P02545

Pathways: Apoptose, Caspase Kaskade in der Apoptose, ER-Nucleus Signaling, Protein targeting to Nucleus