UHRF1 Antikörper (AA 139-298)

Produktnummer ABIN6149909

Produktdetails anti-UHRF1 Antikörper

Target: UHRF1 (Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1))

Bindungsspezifität: AA 139-298

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UHRF1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: MWDETELGLY KVNEYVDARD TNMGAWFEAQ VVRVTRKAPS RDEPCSSTSR PALEEDVIYH VKYDDYPENG VVQMNSRDVR ARARTIIKWQ DLEVGQVVML NYNPDNPKER GFWYDAEISR KRETRTAREL YANVVLGDDS LNDCRIIFVD EVFKIERPGE

Kreuzreaktivität: Maus

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 139-298 of human UHRF1 (NP_037414.3).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu UHRF1

Target: UHRF1 (Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1))

Andere Bezeichnung: UHRF1 (UHRF1 Produkte)

Synonyme: ICBP90 antikoerper, Np95 antikoerper, RNF106 antikoerper, hNP95 antikoerper, hUHRF1 antikoerper, AL022808 antikoerper, NP95 antikoerper, fb97f09 antikoerper, wu:fb97f09 antikoerper, zgc:63539 antikoerper, UHRF1 antikoerper, ubiquitin like with PHD and ring finger domains 1 antikoerper, ubiquitin-like, containing PHD and RING finger domains, 1 antikoerper, ubiquitin-like with PHD and ring finger domains 1 antikoerper, UHRF1 antikoerper, Uhrf1 antikoerper, uhrf1 antikoerper

Hintergrund: This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.,UHRF1,ICBP90,Np95,RNF106,TDRD22,hNP95,hUHRF1,huNp95,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Apoptosis,UHRF1

Molekulargewicht: 89 kDa/91 kDa

Gen-ID: 29128

UniProt: Q96T88