UHRF1 Antikörper (AA 616-755)
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- Target Alle UHRF1 Antikörper anzeigen
- UHRF1 (Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1))
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Bindungsspezifität
- AA 616-755
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser UHRF1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)
- Aufreinigung
- purified
- Immunogen
- Purified recombinant fragment of human UHRF1 (AA: 616-755) expressed in E. coli.
- Klon
- 2A8C7
- Isotyp
- IgG1
- Top Product
- Discover our top product UHRF1 Primärantikörper
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- Applikationshinweise
- ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: , FCM:
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- 4°C, -20°C for long term storage
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- Target
- UHRF1 (Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1))
- Andere Bezeichnung
- UHRF1 (UHRF1 Produkte)
- Synonyme
- ICBP90 antikoerper, Np95 antikoerper, RNF106 antikoerper, hNP95 antikoerper, hUHRF1 antikoerper, AL022808 antikoerper, NP95 antikoerper, fb97f09 antikoerper, wu:fb97f09 antikoerper, zgc:63539 antikoerper, UHRF1 antikoerper, ubiquitin like with PHD and ring finger domains 1 antikoerper, ubiquitin-like, containing PHD and RING finger domains, 1 antikoerper, ubiquitin-like with PHD and ring finger domains 1 antikoerper, UHRF1 antikoerper, Uhrf1 antikoerper, uhrf1 antikoerper
- Hintergrund
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Description: This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.,
Aliases: Np95, hNP95, ICBP90, RNF106, TDRD22, hUHRF1, huNp95
- Molekulargewicht
- 89.8 kDa
- Gen-ID
- 29128
- HGNC
- 5335
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