Heat Shock Protein 90kDa alpha (Cytosolic), Class B Member 1 (HSP90AB1) (N-Term) Antikörper

Details zu Produkt Nr. ABIN614808, Anbieter: Anmelden zum Anzeigen
Antigen
  • D6S182
  • HSP84
  • HSP90B
  • HSPC2
  • HSPCB
  • hsp90b
  • 90kDa
  • AL022974
  • C81438
  • Hsp84
  • Hsp84-1
  • Hsp90
  • Hspcb
  • HSP90-BETA
  • hsp90beta
  • wu:fa29f01
  • wu:fa91e11
  • wu:fd59e11
  • wu:gcd22h07
  • HSP90
  • heat shock protein 90 alpha family class B member 1
  • Heat Shock Protein 90, endoplasmic reticulum
  • heat shock protein 90B
  • heat shock protein 90 alpha (cytosolic), class B member 1
  • heat shock protein 90kDa alpha family class B member 1 S homeolog
  • heat shock protein 90, alpha (cytosolic), class B member 1
  • HSP90AB1
  • HSP90B
  • hsp90ab1
  • Hsp90ab1
  • hsp90ab1.S
Epitop
N-Term
49
35
25
22
16
13
12
7
7
6
5
4
4
3
3
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
Reaktivität
Rind (Kuh), Human, Maus
339
231
185
34
27
18
13
13
5
5
4
3
3
3
3
2
2
2
2
2
1
1
1
1
1
Wirt
Maus
191
147
1
Klonalität (Klon)
Monoklonal ()
Konjugat
Unkonjugiert
12
11
9
6
6
6
6
6
5
5
5
5
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
298
181
138
131
107
81
57
39
14
13
11
10
5
2
2
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen Peptide within N-terminal part of human Hsp90
Sequenz EEVHHGEEEV EC
Klon MBH90B
Isotyp IgG1
Spezifität This antibody recognizes the EEVHHG epitope within the N-terminal part of Hsp90 beta an ubiquitously expressed protein with calculated Mw of 83.3 kDa, however, migrating as a 90 kDa band under reducing SDS-PAGE conditions.
Kreuzreaktivität (Details) Species reactivity (tested):Human, Mouse, Bovine
Reinigung Protein-A affinity chromatography
Reinheit > 95 % pure by SDS-PAGE
Andere Bezeichnung HSP90AB1 / HSP90 beta (HSP90AB1 Antibody Abstract)
Hintergrund Hsp90 beta (heat shock protein 90 beta) is a constitutively expressed isoform of Hsp90, one of the most abundant chaperones in the cytosol of eukaryotic cells. Hsp90 interacts with various proteins, including protein kinases and transcription factors, and either facilitates their stabilization and activation or directs them for proteasomal degradation. Hsp90 thus affects multiple signaling pathways and biological processes and modulation of this single target offers the prospect of simultaneous intervence to various key points of oncogenic transformation. Hsp90 operates as a dimer in a conformational cycle driven by ATP binding and hydrolysis.Synonyms: HSP84, HSP90B, HSPC2, HSPCB, Heat shock 84 kDa, Heat shock protein HSP 90-beta
Gen-ID 3326
NCBI Accession NP_031381
UniProt P08238
Pathways Regulation of Cell Size
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1.0 mg/mL
Buffer Phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2 % (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Bilder des Herstellers
Western Blotting (WB) image for anti-Heat Shock Protein 90kDa alpha (Cytosolic), Class B Member 1 (HSP90AB1) (N-Term) antibody (ABIN614808) anti-Heat Shock Protein 90kDa alpha (Cytosolic), Class B Member 1 (HSP90AB1) (N-Term) antibody
Allgemeine Veröffentlichungen Pearl, Prodromou, Workman: "The Hsp90 molecular chaperone: an open and shut case for treatment." in: The Biochemical journal, Vol. 410, Issue 3, pp. 439-53, 2008 (PubMed).

Millson, Truman, Rácz, Hu, Panaretou, Nuttall, Mollapour, Söti, Piper et al.: "Expressed as the sole Hsp90 of yeast, the alpha and beta isoforms of human Hsp90 differ with regard to their capacities for activation of certain client proteins, whereas only Hsp90beta generates ..." in: The FEBS journal, Vol. 274, Issue 17, pp. 4453-63, 2007 (PubMed).

Hooven, Yamamoto, Jeffery: "Blind cavefish and heat shock protein chaperones: a novel role for hsp90alpha in lens apoptosis." in: The International journal of developmental biology, Vol. 48, Issue 8-9, pp. 731-8, 2004 (PubMed).

Pratt: "The hsp90-based chaperone system: involvement in signal transduction from a variety of hormone and growth factor receptors." in: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), Vol. 217, Issue 4, pp. 420-34, 1998 (PubMed).

Scheibel, Buchner: "The Hsp90 complex--a super-chaperone machine as a novel drug target." in: Biochemical pharmacology, Vol. 56, Issue 6, pp. 675-82, 1998 (PubMed).

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