PCSK1 Antikörper (AA 604-753)

Produktnummer ABIN6145322

Produktdetails anti-PCSK1 Antikörper

Target: PCSK1 (Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1))

Bindungsspezifität: AA 604-753

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PCSK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Sequenz: PRVYTSYNTV QNDRRGVEKM VDPGEEQPTQ ENPKENTLVS KSPSSSSVGG RRDELEEGAP SQAMLRLLQS AFSKNSPPKQ SPKKSPSAKL NIPYENFYEA LEKLNKPSQL KDSEDSLYND YVDVFYNTKP YKHRDDRLLQ ALVDILNEEN

Kreuzreaktivität: Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 604-753 of human PCSK1 (NP_000430.3).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu PCSK1

Target: PCSK1 (Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1))

Andere Bezeichnung: PCSK1 (PCSK1 Produkte)

Synonyme: BMIQ12 antikoerper, NEC1 antikoerper, PC1 antikoerper, PC3 antikoerper, SPC3 antikoerper, Nec-1 antikoerper, Nec1 antikoerper, Phpp-1 antikoerper, BDP antikoerper, PC1/3 antikoerper, proprotein convertase subtilisin/kexin type 1 antikoerper, prohormone convertase 1 antikoerper, PCSK1 antikoerper, Pcsk1 antikoerper, pcsk1 antikoerper, PC1B antikoerper

Hintergrund: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. The protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene,PCSK1,BMIQ12,NEC1,PC1,PC3,SPC3,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Growth factor,Ubiquitin,Endocrine & Metabolism,Neuroscience,PCSK1

Molekulargewicht: 79 kDa/84 kDa

Gen-ID: 5122

UniProt: P29120

Pathways: Peptide Hormone Metabolism