AFT7 Antikörper (AA 1-117)

Produktnummer ABIN6223488

Produktdetails anti-AFT7 Antikörper

Target: AFT7 (Activating Transcription Factor 7 (AFT7))

Bindungsspezifität: AA 1-117

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AFT7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: MGDDRPFVCN APGCGQRFTN EDHLAVHKHK HEMTLKFGPA RTDSVIIADQ TPTPTRFLKN CEEVGLFNEL ASSFEHEFKK AADEDEKKAR SRTVAKKLVV FRPRLFLLCF GIIFLIG

Kreuzreaktivität: Human

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-117 of human ATF7 (NP_001193611.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu AFT7

Target: AFT7 (Activating Transcription Factor 7 (AFT7))

Andere Bezeichnung: ATF7 (AFT7 Produkte)

Synonyme: ATFA antikoerper, 1110012F10Rik antikoerper, 9430065F09Rik antikoerper, AI549878 antikoerper, C130020M04Rik antikoerper, ATF7 antikoerper, fa97a09 antikoerper, fc25b12 antikoerper, wu:fa97a09 antikoerper, wu:fc25b12 antikoerper, atfa antikoerper, activating transcription factor 7 antikoerper, activating transcription factor 7b antikoerper, ATF7 antikoerper, Atf7 antikoerper, atf7b antikoerper, atf7 antikoerper

Hintergrund: Stress-responsive chromatin regulator that plays a role in various biological processes including innate immunological memory, adipocyte differentiation or telomerase regulation. In absence of stress, contributes to the formation of heterochromatin and heterochromatin-like structure by recruiting histone H3K9 tri- and di-methyltransferases thus silencing the transcription of target genes such as STAT1 in adipocytes, or genes involved in innate immunity in macrophages and adipocytes (By similarity. Stress induces ATF7 phosphorylation that disrupts interactions with histone methyltransferase and enhances the association with coactivators containing histone acetyltransferase and/or histone demethylase, leading to disruption of the heterochromatin-like structure and subsequently transcriptional activation (By similarity. In response to TNF-alpha, which is induced by various stresses, phosphorylated ATF7 and telomerase are released from telomeres leading to telomere shortening. Plays also a role in maintaining epithelial regenerative capacity and protecting against cell death during intestinal epithelial damage and repair (By similarity.,ATF7,ATFA,Epigenetics & Nuclear Signaling,Transcription Factors,ATF7

Molekulargewicht: 13 kDa/33 kDa/49 kDa/50 kDa/51 kDa/52 kDa

Gen-ID: 11016

UniProt: P17544