Clusterin Antikörper

Produktnummer ABIN5962710

Produktdetails anti-Clusterin Antikörper

Target: Clusterin (CLU)

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Clusterin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: 40,AAG 4,AAG4,Aging associated protein 4,Aging-associated gene 4 protein,AI893575,APO J,Apo-J,APOJ,ApoJalpha,ApoJbeta,Apolipoprotein J,ApolipoproteinJ,CLI,CLU,CLU1,CLU2,CLUS,Clusterin alpha chain,Clusterin,Clusterin beta chain,Complement associated protein SP 40 40,Complement associated protein SP 40,Complement associated protein SP40,Complement cytolysis inhibitor a chain,Complement cytolysis inhibitor,Complement cytolysis inhibitor b chain,Complement lysis inhibitor,Complement-associated protein SP-40,D14Ucla3,Dimeric acid glycoprotein,Glycoprotein 80,Glycoprotein III,GP80,Ku70-binding protein 1,KUB 1,KUB1,MGC24903,NA1/NA2,RATTRPM2B,SGP 2,SGP2,SP 40,SP40,Sugp-2,Sulfated glycoprotein 2,Testosterone repressed prostate message 2,Testosterone-repressed prostate message 2,TRPM 2,TRPM-2,TRPM2,TRPM2B,Trpmb

Aufreinigung: Affinity purification

Immunogen: Synthesized peptide derived from human CLUS Polyclonal

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-2000, ELISA 1:10000-20000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide,0.5 % BSA and 50 % glycerol  pH 7.4.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Clusterin

Target: Clusterin (CLU)

Andere Bezeichnung: CLUS (CLU Produkte)

Synonyme: LOC100136120 antikoerper, clu antikoerper, MGC53055 antikoerper, zgc:73352 antikoerper, xclu antikoerper, MGC89163 antikoerper, CLU antikoerper, APO-J antikoerper, APOJ antikoerper, CLI antikoerper, CLU1 antikoerper, CLU2 antikoerper, KUB1 antikoerper, NA1/NA2 antikoerper, SGP-2 antikoerper, SGP2 antikoerper, SP-40 antikoerper, TRPM-2 antikoerper, TRPM2 antikoerper, DAG antikoerper, RATTRPM2B antikoerper, SP40 antikoerper, TRPM2B antikoerper, Trpm2 antikoerper, Trpmb antikoerper, AI893575 antikoerper, ApoJ antikoerper, Cli antikoerper, D14Ucla3 antikoerper, Sgp-2 antikoerper, Sgp2 antikoerper, Sugp-2 antikoerper, GP80 antikoerper, gpIII antikoerper, 40 antikoerper, clusterin-1 antikoerper, clusterin L homeolog antikoerper, clusterin antikoerper, Clusterin antikoerper, LOC100136120 antikoerper, clu.L antikoerper, clu antikoerper, CLU antikoerper, clus antikoerper, Clu antikoerper, LOC101113728 antikoerper

Hintergrund: Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.

Gen-ID: 1191

UniProt: P10909

Pathways: Apoptose, Negative Regulation of intrinsic apoptotic Signaling