YTHDC1 Antikörper

Produktnummer ABIN5705285

Produktdetails anti-YTHDC1 Antikörper

Target: YTHDC1 (YTH Domain Containing 1 (YTHDC1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser YTHDC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Immunogen: YTH domain containing 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB : 1:200-1:1000

Kommentare:

MCF-7 cells were subjected to SDS PAGE followed by western blot with FNab09571( YTHDC1 Antibody) at dilution of 1:300

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu YTHDC1

Target: YTHDC1 (YTH Domain Containing 1 (YTHDC1))

Andere Bezeichnung: YTHDC1 (YTHDC1 Produkte)

Synonyme: C80342 antikoerper, mKIAA1966 antikoerper, A730098D12Rik antikoerper, zgc:101592 antikoerper, MGC89461 antikoerper, MGC137509 antikoerper, DKFZp459L1228 antikoerper, YT521 antikoerper, YT521-B antikoerper, Yt521 antikoerper, YTH domain containing 1 antikoerper, YTH domain containing 1 L homeolog antikoerper, Ythdc1 antikoerper, YTHDC1 antikoerper, ythdc1 antikoerper, ythdc1.L antikoerper

Hintergrund: Synonyms:KIAA1966, Putative splicing factor YT521, YT521, YT521 B, YTH domain containing 1, YTHDC1 Background:Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine(m6A)-containing RNAs(PubMed:26318451, PubMed:26876937, PubMed:25242552). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability(PubMed:26318451, PubMed:25242552). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10(PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing(PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing(PubMed:26876937). May also regulate alternative splice site selection(PubMed:20167602).

Molekulargewicht: 14kDa

Gen-ID: 91746

UniProt: Q96MU7