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YTHDC1 Antikörper

YTHDC1 Reaktivität: Human, Maus, Ratte ELISA, WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7120901
  • Target Alle YTHDC1 Antikörper anzeigen
    YTHDC1 (YTH Domain Containing 1 (YTHDC1))
    Reaktivität
    • 13
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 13
    Kaninchen
    Klonalität
    • 13
    Polyklonal
    Konjugat
    • 9
    • 2
    • 1
    • 1
    Dieser YTHDC1 Antikörper ist unkonjugiert
    Applikation
    • 8
    • 5
    • 4
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB)
    Aufreinigung
    Immunogen affinity purified
    Reinheit
    ≥95 % as determined by SDS-PAGE
    Immunogen
    YTH domain containing 1
    Isotyp
    IgG
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  • Applikationshinweise
    WB: 1:200-1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Haltbarkeit
    12 months
  • Target
    YTHDC1 (YTH Domain Containing 1 (YTHDC1))
    Andere Bezeichnung
    YTHDC1 (YTHDC1 Produkte)
    Synonyme
    C80342 antikoerper, mKIAA1966 antikoerper, A730098D12Rik antikoerper, zgc:101592 antikoerper, MGC89461 antikoerper, MGC137509 antikoerper, DKFZp459L1228 antikoerper, YT521 antikoerper, YT521-B antikoerper, Yt521 antikoerper, YTH domain containing 1 antikoerper, YTH domain containing 1 L homeolog antikoerper, Ythdc1 antikoerper, YTHDC1 antikoerper, ythdc1 antikoerper, ythdc1.L antikoerper
    Hintergrund
    Synonyms:KIAA1966, Putative splicing factor YT521, YT521, YT521 B, YTH domain containing 1, YTHDC1 Background:Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine(m6A)-containing RNAs(PubMed:26318451, PubMed:26876937, PubMed:25242552). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability(PubMed:26318451, PubMed:25242552). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10(PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing(PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing(PubMed:26876937). May also regulate alternative splice site selection(PubMed:20167602).
    Molekulargewicht
    110 kDa
    Gen-ID
    91746
    UniProt
    Q96MU7
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