ZC3HAV1 Antikörper

Produktnummer ABIN5705199

Produktdetails anti-ZC3HAV1 Antikörper

Target: ZC3HAV1 (Zinc Finger CCCH-Type, Antiviral 1 (ZC3HAV1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZC3HAV1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Immunogen: zinc finger CCCH-type, antiviral 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:1000-1:10000,IHC:1:20-1:200,IP:1:1000-1:10000

Kommentare:

HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab09606( ZC3HAV1 Antibody) at dilution of 1:4000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu ZC3HAV1

Target: ZC3HAV1 (Zinc Finger CCCH-Type, Antiviral 1 (ZC3HAV1))

Andere Bezeichnung: ZC3HAV1 (ZC3HAV1 Produkte)

Synonyme: 1200014N16Rik antikoerper, 2900058M19Rik antikoerper, 9130009D18Rik antikoerper, 9830115L13Rik antikoerper, ARTD13 antikoerper, D6Bwg1452e antikoerper, ZAP antikoerper, Zap antikoerper, FLB6421 antikoerper, PARP13 antikoerper, ZC3H2 antikoerper, ZC3HDC2 antikoerper, zinc finger CCCH type, antiviral 1 antikoerper, zinc finger CCCH-type containing, antiviral 1 antikoerper, Zc3hav1 antikoerper, ZC3HAV1 antikoerper

Hintergrund: Synonyms:DKFZp686F2052, DKFZp686H1869, DKFZp686O19171, FLB6421, FLJ13288, ZAP, ZC3H2, ZC3HAV1, ZC3HDC2, Zinc finger antiviral protein Background:Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element(ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72(DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1(HIV-1), moloney and murine leukemia virus(MoMLV) and xenotropic MuLV-related virus(XMRV), filoviridae: ebola virus(EBOV) and marburg virus(MARV), togaviridae: sindbis virus(SINV) and Ross river virus(RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes(ISGs).

Molekulargewicht: 34kDa

Gen-ID: 56829

UniProt: Q7Z2W4